Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2015.178.185UpaganlawarAman BalaramanR. 5201565Background: The present study was planned to assess the cardioprotective effects of Pomegranate fruit extract alone and along with vitamin E by evaluating electrocardiographic changes and biochemical changes in isoproterenol (ISO) induced myocardial infarction in rats. Materials and Methods: Myocardial infarction was induced by subcutaneous injection of isoproterenol (200 mg kg-1) for two consecutive days at an interval of 24 h. Rats were treated with pomegranate (100 mg kg-1 day-1, p.o.) and vitamin E (50 mg kg-1 day-1, p.o.) for a period of 30 days and isoproterenol was injected on 29th and 30th day. On day 31st electrocardiographic changes and biochemical changes were monitored from all the experimental groups. Results: Isoproterenol injected rats showed a significant alteration in ECG pattern. It also showed significant increase in C-reactive protein, myeloperoxidase levels, lipid peroxidation and Caspase-3 protease activity. In addition, it also exhibited alteration in the levels of electrolytes (Na+, K+ and Ca++). Significant alteration of ATPases was also observed. Treatment with Pomegranate fruit extract alone and along with vitamin E significantly prevented the isoproterenol induced alteration in electrographic changes and other biochemical alterations. Conclusion: The present result showed that treatment of pomegranate fruit extract alone and along with vitamin E in ISO injected rats significantly attenuates myocardial infarction.]]>Murray, C.J. and A.D. Lopez,19961996Pandey, K.B. and S.I. Rizvi,20092270278Upaganlawar, A., C. Gandhi and R. Balaraman,2009647580Upaganlawar, A. and R. Balaraman,20102135141Upaganlawar, A., V. Patel and R. Balaraman,20122345351 Upaganlawar, A.B. and R. Balaraman, 20123215220Upaganlawar, A. and R. Balaraman,2011Lagenaria siceraria fruit juice on isoproterenol-induced myocardial infarction in wistar rats: A biochemical and histoarchitecture study.]]>3297303Lansky, E.P. and R.A. Newman,2007Punica granatum (Pomegranate) and its potential for prevention and treatment of inflammation and cancer.]]>109177206Nandave, M., I. Mohanty, T.C. Nag, S.K. Ojha, R. Mittal, S. Kumari and D.S. Arya,2007222228Ithayarshi, P., V.N. Padmavathy and C.S.S. Devi,199640297302Punithavathi, V.R. and P.S.M. Prince,201086178184Punithavathi, V.R. and P.S.M. Prince,2009181322327McKenzie, D. and A.R. Henderson,198329189195Bonting, S.L.,19701970pp: 254-363pp: 254-363Hjerten, S. and H. Pan,19832+-ATPase from erythrocyte membranes.]]>728281288Ohnishi, T., T. Suzuki, Y. Suzuki and K. Ozawa,19822+-ATPase activities in normal, regenerating and malignant cells.]]>6846774Bradley, P.P., D.A. Priebat, R.D. Christensen and G. Rothstein,198278206209Slater, T.F. and B.C. Sawyer,1971in vitro. General features of the systems used.]]>123805815Peacock, W.F., J.E. Hollander, R.W. Smalling and M.J. Bresler,200725353366Rajadurai, M. and P.S.M. Prince,2007230178188Manjula, T.S. and C.S. Devi,1993983033Niskanen, L.K., D.E. Laaksonen, K. Nyyssonen, G. Alfthan, H.M. Lakka, T.A. Lakka and J.T. Salonen,200416415461551McCord, J.M.,19884914Ithayarshi, P., V.N. Padmavathy and C.S.S. Devi,199640297302Jennings, R.B., K.A. Reimer and C. Steenbergen,198618769780Chun, O.K., S.J. Chung and W.O. Song,200713712441252Senthil, S., M. Sridevi and K.V. Pugalendi,200735418423Sathish, V., K.K. Ebenezar and T. Devaki,2003243133138Jayachandran, K.S., H.R. Vasanthi and G.V. Rajamanickam,2009327203210Adameova, A., Y. Abdellatif and N.S. Dhalla,200987493514Galang, N., H. Sasaki and N. Maulik,2000148111118