Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2015.141.148AkhlaqMuhammad MansourHeba F.AbdelkaderHamdy 4201564Background and Objective: Maltodextrin was investigated as a novel excipient for preparation of Orally Disintegrated Tablets (ODT) of Flurbiprofen (FLB), Diclofenac Sodium (DCL) or Pioglitazone HCl (PGL). Methods: A simple preparation technique, wet granulation method was used. The prepared ODT were physically characterized for mechanical properties. In-vitro and in-vivo disintegration time and drug release as well as accelerated stability have also been investigated. Results: The recorded hardness and friability were approximately 4 kg and less than 1% respectively. The prepared ODT revealed very fast in vitro and in-vivo disintegration and drug release. A good correlation (R2 = 0.986) between in vitro and in-vivo disintegration time was obtained. The prepared tablets exhibited significantly higher plasma maximum concentration (Cmax) and lower time for Cmax (Tmax) compared to the commercial tablets. Further, the accelerated stability studies indicated that the ODT have good mechanical and physical properties. Conclusion: This report warrants maltodextrin as a potential and reliable candidate for preparation of ODT.]]>Alderborn, G.,20072007pp: 441-482pp: 441-482FDA.,20082008Elnaggar, Y., M.A. El-Massik, O.Y. Abdallah and A.R. Ebian,201011645651Kuno, Y., M. Kojima, H. Nakagami, E. Yonemochi and K. Terada,200869986992Mizumoto, T., Y. Masuda, T. Yamamoto, E. Yonemochi and K. Terada,20053068390Sunada, H. and Y. Bi,2002122188198Llinas, A., J.C. Burley, K.J. Box, R.C. Glen and J.M. Goodman,200750979983Abdelkader, H., O. Y. Abdalla and H. Salem,2008in vitro evaluation.]]>9675683Akhlaq, M., G.M. Khan, A. Wahab, A. Khan, A. Hussain, A. Nawaz and H.A. Abdelkader,20112151155