Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2014.98.106in vivo Antioxidant Properties
of the Bark of Ficus amplissima Smith]]>ArunachalamKaruppusamy ParimelazhganThangaraj 3201453Background: Herbal preparations of Ficus amplissima had been considered
as effective, economical and safe ethnomedicines for various ailments in Indian
traditional system of medicine. The present study was aimed to explore scientifically
the antioxidant, anti-inflammatory and wound healing potential of Ficus amplissima
bark. Materials and Methods: In the present study, the methanol extract
of F. amplissima bark were studied for enzymatic antioxidant activity
through different assays, anti-inflammatory by using egg albumin induced inflammation
and cotton pellet induced granuloma models (100 and 200 mg methanol extract)
and wound healing activity by incorporating the two doses (1 and 2% (w/w)) of
methanol extract and simple ointment base B.P. in concentration of 5% (w/w)
using excision and incision wound models in rats. In case of the excision wound
model, wound contraction and period of epithelization was studied while incision
wound model was evaluated by determining tensile strength. Results:F. amplissima bark expressed the potent anti-inflammatory and in vivo
antioxidant activity, where, 200 mg methanol extracts showed higher activity.
Treatment of wound with ointment containing 2% (w/w) methanol extract was exhibited
significant (p<0.001) wound healing activity. Conclusion: The methanol
extract of F. amplissima bark exhibited better anti-inflammatory, wound
healing and in vivo antioxidant activity most likely due to phenols constituents.]]>Aebi, H.,19741974pp: 673-684pp: 673-684Anonymous,20092009Bayliss, M.T.,19841984pp: 55pp: 55Charles, V.M., R.C.G. Rusell and N.S. Williams,199520th Edn.,pp: 9-11pp: 9-11Dissemond, J., M. Goos and S.N. Wagner, 200253718723 Reddy, B.S., R.K.K. Reddy, V.G.M. Naidu, K. Madhusudhana, S.B. Agwane, S. Ramakrishna and P.V. Diwan,2008Holoptelea integrifolia.]]>115249256Enoch, S. and D.J. Leaper,2005233742Kumar, B., M. Vijayakumar, R. Govindarajan and P. Pushpangadan,2007114103113Gupta, A., R.L. Singh and R. Roghubir,200224117Li, H., X. Lu, S. Zhang, M. Lu and H. Liu,2008Pholiota nameko.]]>73669675Halliwell, B., J.M. Gutteridge and M. Grootveld,1988335990Ionac, M., M.J. Parnham, M. Plauchithiu and K. Brune,199633367373Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.I. Randall,1951193438448Marklund, S. and G. Marklund,197447469474McManus, J.F.A. and R.W. Mowry,19601st Edn.pp: 57pp: 57Singh, M., R. Govindarajan, V. Nath, A.K.S. Rawat and S. Mehrotra,2006Plagiochasma appendiculatum Lehm. et Lind.]]>1076772White, M.J. and F.R. Heckler,19901714731483Moyer, K.E., G.C. Saggers, G.M. Allison, D.R. Mackay and H.P. Ehrlich,2002193173179Mukherjee, P.K., R. Verpoorte and B. Suresh,2000in-vivo wound healing activity of Hypericum patulum (Family: Hypericaceae) leaf extract on different wound model in rats.]]>70315321Murugan, R., Arunachalam, K., T. Parimelazhagan,2012Ficus amplissima Smith) bark.]]>215967Kumar, M.S., S. Kirubanandan, R. Sripriya and P.K. Sehgal,200814494101Nayak, B.S. M. Anderson and P. Pereire,2007Catharanthus roseus leaf extract in rats.]]>78540544OECD,198740217Ohkawa, H., N. Ohishi and K. Yagi,197995351358Okokon, J.E. and P.A. Nwafor,2010Croton zambesicus.]]>23114118Oudhia, P.,2012Linum usitatissium L) and sanjeevani (Sellaginella bryophytes (L) Baker Based herbal formulations in Indian traditional healing for diabeties complications.]]>2012Rane, M.M. and S.A. Mengi,2003Terminalia arjuna bark on incision and excision wounds in rats.]]>74553558Scortichini, M. and M.P. Rossi,1991in vitro evaluation of the antimicrobial activity of terpenes and terpenoids towards Erwinia amylovora (Burrill) Winslow et al.]]>71109112Seibert, K., Y. Zhang, K. Leahy, S. Hauser and J. Masferrer et al.,1994911201312017Kumar, M.S., R. Sripriya, H.V. Raghavan and P.K. Sehgal,2006Cassia fistula on infected albino rat model.]]>131283289Sumitra, M., P. Manikandan and L. Suguna,2005Butea monosperma on dermal wound healing in rats.]]>37566573Trowbridge, J.M. and R.L. Gallo,200212117R125RTsuchiya, H., M. Sato, T. Miyazaki, S. Fujiwara and S. Tanigaki et al.,1996Staphylococcus aureus.]]>502734Udupa, A.L., D.R. Kulkarni and S.L. Udupa,1995Tridax procumbens extracts on wound healing.]]>333740Weindl, G., M. Schaller and H.C. Korting,200417207213Winter, C.A. and C.C. Porter,195746515519