Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2014.177.183Mucuna pruriens
in Alloxan-induced Biochemical Alteration in Male Wistar Rats]]>MajekodunmiStephen O. OyagbemiAdemola A. OdekuOluwatoyin A. 5201455Backgournd: To evaluate the ameliorative effect of ethanolic seed extract
of Mucuna pruriens in alloxan-induced biochemical alteration in male
Wistar rats. Materials and Methods: Ethanolic seed extract of Mucuna
pruriens was administered orally in doses of 5, 10, 20, 30, 40, 50 and 100
mg kg-1 body weight (b.wt.) to alloxan-induced rats. The plasma biochemical
and lipid profiles and the histopathological evaluation of the liver of the
normal and diabetic rats were carried out and the results compared with those
diabetic rats administered with M. pruriens extract and glibenclamide
(5 mg kg-1 body weight). Results: The alloxan treated rats
showed significantly (p<0.05) elevated levels of plasma cholesterol, triglycerides,
urea, creatinine, serum aspartate aminotransferase and serum alanine aminotransferase
with concomitant decreased in total protein level when compared to the control
rats. Administration of M. pruriens seed extract and glibenclamide significantly
(p<0.05) decreased the plasma cholesterol, triglycerides, low density lipoprotein-cholesterol,
creatinine, alkaline phosphatase levels while high density lipoprotein-cholesterol
levels significantly (p<0.05) increased after 12 weeks of treatment of the
diabetic rats. The effect of M. pruriens seed extract was dose dependent
and the plasma and lipid profiles and the electrolytes levels were restored
to near normal levels. There were no significant (p>0.05) difference in the
ameliorative effect of M. pruriens extract and glibenclamide. Conclusion:
Mucuna pruriens ethanolic seed extract has both hepatoprotective and lypogenic
activities in alloxan induced diabetic rats and could be substituted for standard
oral hypoglycaemic agent. Mucuna pruriens extract in addition to possessing
hypoglycaemic properties could be used to ameliorate the biochemical alterations
induced by diabetes.]]>Akhtar, M.S., A.Q. Qureshi and J. Iqbal,1990Mucuna pruriens, Linn seeds.]]>40147150Allain, C.C., L.S. Poon, C.S.G. Chan, W. Richmond and P.C. Fu,197420470475Barter, P.J., S. Nicholls, K.A. Rye, G.M. Anantharamaiah, M. Navab and A.M. Fogelman,200495764772Bergmeyer, H.U., M.R. Horder and R. Rej,198524418489Bhaskar, A., V.G. Vidhya and M. Ramya,2008Mucuna pruriens seed extract on normal and streptozotocin-diabetic rats.]]>79539543Bucolo, G. and H. David,197319476482Carroll, P. and R. Matz,19836579585Davi, G., A. Falco and C. Patrono,20057256268Davis, S.N.,20062006pp: 1613-1645pp: 1613-1645Dhawan, B.N., M.P. Dubey, B.N. Mehrotra, R.P. Rastogi and J.S. Tandon,198018594606Falchuk, K.R. and D. Conlin,199338269286Friedewald, W.T., R.I. Levy and D.S. Fredrickson,197218499502Gordon, T., W.P. Castelli, M.C. Hjortland, W.B. Kannel and T.R. Dawber,197762707714Hardman, J.G. and L.E. Limbard,20012001pp: 1383-1399pp: 1383-1399Harrison, G.A.,19471947pp: 259-274pp: 259-274Jarrett, R.J., H. Keen and R. Chakrabarti,19821982Klauke, R., E. Schmidt and K. Lorentz,198831901909Kolthoff, I.M. and P.J. Elving,1976Vol. 15,pp: 15-100pp: 15-100Kumar, G., G.S. Banu, P.V. Pappa, M. Sundararajan and M.R. Pandian, 2004Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats.]]>923740Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275Luna, L.G.,19683rd Edn.,Pages: 258Pages: 258Majekodunmi, S.O., A.A. Oyagbemi, S. Umukoro and O.A. Odeku,2011Mucuna pruriens seed extract.]]>4632636Matz, R.,19941994pp: 845-860pp: 845-860Nathan, D.M., P.A. Cleary, J.Y. Backlund, S.M. Genuth and J.M. Lachin et al.,200535326432653Negre-Salvayre, A., N. Dousset, G. Ferretti, T. Bacchetti, G. Curatola and R. Salvayre,20064110311040Nicholls, S.J., K.A. Rye and P.J. Barter,200516345349Obaid, M. and J.R. Turtle,200452934Oyagbemi, A.A. and A.A. Odetola,2010Cnidoscolus aconitifolius on paracetamol-induced hepatic damage in rats.]]>13164169Panunti, B., A.A. Jawa and V.A. Fonseca,20041151157Patel, K.N., G. Gupta, M. Goyal and B.P. Nagori,2011Tecomella undulate on paracetamol-induced hepatotoxicity in rats.]]>21133138Rajesh, M.G. and M.S. Latha,20049199104Rathi, S.S., J.K. Grover and V. Vats,2002Momordica charantia and Mucuna pruriens in experimental diabetes and their effect on key metabolic enzymes involved in carbohydrate metabolism.]]>16236243Rollason, J.G., G. Pincherle and D. Robinson,1972397580Sallie, R., J.M. Tredger and R. Williams,199112251259Saraswat, B., P.K. Visen G.K. Patnaik and B.N. Dhawan,1993Picrorhiza kurrooa, against carbon tetrachloride induced cholestasis.]]>31316318Schaefer, E.J., J.R. McNamara, P.K. Shah, K. Nakajima and L.A. Cupples et al.,200225989994Schales, O. and S.S. Schales,1971140879879Schlebusch, H., C. Schneider and N. Liappis,199569595Sherlock, S. and J. Dooley,19939th Edn.,Silva, F.R.M.B., B. Szpoganicz, M.G. Pizzolatti, M.A. Willrich and E. de Sousa,2002Bauhinia forficata on serum glucose levels in normal and alloxan-induced diabetic rats.]]>833337Stocker, R., Y. Yamamoto, A.F. McDonagh, A.N. Glazer and B.N. Ames,198723510431046Szasz, K.,19741974pp: 715pp: 715Tietz, N.W. and D.F. Shuey,19863215931594Van Slyke, W. and H.S. Aulle,1971pp: 112-197pp: 112-197Wingard, D.L., E. Barrdt-Conner, M.H. Criqui and L. Suarez,19831171926Yamini, B.T. and K.U. Anil,2001Mucuna pruriens Linn.]]>8013771378