Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2014.127.134IslamMd. Toriqul ChowdhuryMohammed Rashed HossainMd. Anwar IslamMd. Siddiqul 4201454Background: Spirulina have been considered as a potential therapeutic supplement
due to its ability to minimize several element induced toxicities in various
species including man. The present study was designed to evaluate the potentiality
of spirulina in arsenic induced toxic mice. Materials and Methods: Fifty
mice were divided into 5 equal groups, including a control group (T0).
Arsenic trioxide (1 mg/2 mL drinking water) was administered in one group of
mice (TA), whereas the remaining three groups of mice (TB,
TC and TD) were given arsenic trioxide (1 mg) plus spirulina
(at different doses) in drinking water daily for 90 days. Toxic signs, body
weight, hematological and biochemical parameters were recorded at 15 day intervals.
Results: Sudden onset of depression, restlessness, anorexia, ruffled
hair coat and skin lesions in all parts of the body, especially on tail region
of the arsenic trioxide administered mice were found that was mild in nature
in other four groups. Biochemical and hematological studies explored that the
mean body weight, the values of Total Erythrocyte Count (TEC), Hemoglobin (Hb)
and Packed Cell Volume (PCV) were significantly reduced (p<0.01), whereas
the values of Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate
Oxaloacetate Transaminase (SGOT) and Alkaline Phosphatase (ALP) were significantly
increased (p<0.01) in arsenic trioxide administered mice when compared with
control group (p>0.05) and arsenic trioxide plus spirulina administered groups
(p>0.05). Conclusion: The findings of this study illustrate that spirulina
was found to be effective in the reduction of body burden of arsenic.]]>Akter, J., M.Z. Islam, A.G. Hassan and M.A. Awal,201021520Awal, M.A.,20072007Bulik, C.,19931993pp: 121-131pp: 121-131Chiou, P.W.S., K.L. Chen and B. Yu,199774229236Ciferri, O.,198347551578Dey, R.,20022002Fariduddin, A.K.M., M. Misbahuddin, M.I.R. Manun and N. Nahar,2001171517Friberg, L., G.F. Nordberg and V.B. Vook,19862nd Edn.,pp: 43-83pp: 43-83Romay, C., N. Ledon and R. Gonzalez,199951641642Islam, A.K.M.S., M.A. Awal, A.S.M. Bari, M.M. Rahman, S. Begum and M.S. Islam,200135151153Islam, M.S., M.A. Awal, M. Mostofa, F. Begum, A. Khair and M. Myenuddin,200987579Islam, M.N., M.A. Awal, M.M. Rahman, M.S. Islam and M. Mostofa,200537577Johnson, P.E. and L.E. Shubert,19863410631070Kaur, H., V. Mani and C.S. Mishra,200518497501Kurttio, P., E. Pukkala, H. Kahelin, A. Auvinen and J. Pekkanen,1999107705710Lamberg, S.L. and R. Rothstein,1977Lasky, T., W. Sun, A. Kadry and M.K. Hoffman,20041121821Lau, B.P.Y., P. Michalik and C.J. Porter,198714723732Mahaffey, K.R., S.G. Capar, B.C. Gladen and B.A. Fowler,198198463481Mandal, B.K. and K.T. Suzuki,200258201235Misbahuddin, M., A.Z. Islam, S. Khandker, Ifthaker-Al-Mahmud, N. Islam, Anjumanara,200644135141Mitra, S.R., D.N. Mazumder, A. Basu, G. Block and R. Haque et al.,200411211041109Olayemi, F.O., R.O.A. Arowlo, A.B. Saba and S.A. Fankinde,2002506771Rahman, W.,20062006pp: 6793Richmond, A.,19861986pp: 199-243pp: 199-243Robert, H.,1989Sharma, A., M.K. Sharma and M. Kumar,2007Mentha piperita against arsenic-induced toxicity in liver of Swiss albino mice.]]>100249257Smith, A.H., A. Ercumen, Y. Yuan and C.M. Steinmaus,200919343348Smith, A.H., A.P. Arroyo, D.N.G. Mazumder, M.J. Kosnett and A.L. Hernandez et al.,20006617620WHO,1981pp: 176pp: 176Yang, H., E. Lee and H. Kim,1997Spirulina platensis inhibits anaphylactic reaction.]]>6112371244Yost, L.J., R.A. Schoof and R. Aucoin,19984137152