Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2013.525.528Onosma khyberianum]]>AhmadShakeel KhanMurad Ali AyazSultan AhamdIjaz 9201349Background: The most commonly used plant namely Onosma khyberianum
was brought under antimicrobial study after observing their medicinal values.
The present study aim to assess antimicrobial activity of ethanolic extracts
and subsequent solvent soluble fractions of Onosma khyberianum against
five bacterial strains Salmonella typhi, Shigella dysenteriae,
Escherichia coli, Staphylococcus aureus, Vibrio cholerae
and three fungal strains Aspergilus flavus, Alternaria alternate
and Fusarium oxysporum. Materials and Methods: Briefly the stock
solution of crude extract and other fractions were prepared in DMSO (3 mg mL-1
for antibacterial essay, 4 mg 1 mL-1 for antifungal essay). The antibacterial
activity was evaluated by agar diffusion method while for antifungal assay the
disc diffusion method was used. Results: The ethanolic and chloroform
fractions showed excellent activity against all the selected bacterial strains.
The same fractions also showed best activity against all selected fungal strains.
Conclusion: The present study suggests Onosma khyberianum to
be a source for isolation of antimicrobial compounds for human health care and
use as preservatives in food processing industries.]]>Ali, S.I. and Y.J. Nasir,1989Vol. 191,Cowan, M.M.,199912564582Das, K., R.K.S. Tiwari and D.K. Shrivastava,20104104111Khan, J.A. and S. Tewari,20111028382846Kirtikar, K.R.,1994Vol. 3,Pages: 1698Pages: 1698Kivcak, B., T. Mert and H.T. Ozturk,2009Ceratonia siliqua L. extracts.]]>26197200Levy, S.B.,199410341342Morris, A.K. and R.G. Masterton,200249710Ozgen, U. , P.J. Houghton, Y. Ogundipe and M. Coskun,200374682685Perez, C., M. Paul and P. Bazerque,199015113115Prince, L. and P. Prabakaran,2011Colletotrichum falcatum.]]>18487Sahito, S.R., M.A. Memon, T.G. Kazi, G.H. Kazi, M.A. Jakhrani, Q.U. Haque and G.Q. Shar,2003Azadirchta indica (neem).]]>25139143Naz, S., S. Ahmad, SA. Rasool, S.A. Sayeed and R. Siddiqi,2006Onosma hispidum.]]>1614348Sher, A.,200977278Sibanda, T. and A.I. Okoh,2007628862896Wang, J., A. Galgoci, S. Kodali, K.B. Herath and H. Jayasuriya et al.,20032784442444428