Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2013.511.518MHSAAbdulrahman Alanazi 8201348Background: Obesity in children is becoming a global health problem.
Metformin use to treat obesity in children is increasingly attracting the attention
of clinicians, however, for evidence-based practice, it is important to systematically
analyze the effectiveness of metformin for childhood/adolescence obesity in
clinical trials. Method: Literature search was made in multiple electronic
databases. Methods of analyses comprised meta-analysis (fixed effects model
as well as random effect model) for the determination of statistical significance
between metformin treatment and several variables of study outcomes and meta-regression
analysis for the impact of these variables on metformin treatment. Results:
Eight studies were included in the meta-analysis. Study intervention duration
ranged from 12 to 52 weeks while population size ranged from 28 to 348 participants.
Moreover, Participants age ranged from 6 to 19 years of age. This meta-analysis
reveals significant effect of metformin treatment in reducing BMI with effect
size ranged in magnitude from -3.17 kg m-2 (24) to -0.16 kg m-2
(26). The fixed effects pooled results demonstrated a drop in BMI of 1.08 kg
m-2 with a 95% confidence interval of -1.14 and -0.03 kg m-2
(p<0.01). The random effects model demonstrated a larger effect size with
a value of -1.46 kg m-2 and confidence interval of -1.91 to -1.01
kg m-2 (p<0.01). Metformin tolerability was consistent in all
studies. Conclusion: It is demonstrated that metformin is efficacious
with minor side effects, however, larger trials are required to reach at conclusive
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