Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2013.249.253Benincasa hispida Seeds in Mice]]>BhartiVeni Kiran SharmaSurendra Kumar SinghSumitra 3201343Background: Management of cognitive disorders like dementia and Alzheimers disease has been challenging since no potential drug is available with proved efficacy. Some nootropic drugs like piracetam, aniracetam and cholinesterase inhibitors such as Donepezil® have found to exhibit severe toxic effects in elderly. Aim: In the present study, we assessed the nootropic potential of aqueous and methanol extract of Benincasa hispida on various behavioural models. Method: The young animals treated with aqueous and methanol extract (200 and 400 mg kg-1) showed dose-dependent reduction in transfer latency at both 9th and 10th day by elevated plus maze, morris water maze and object recognition task. Conclusion: From the results, it was concluded that methanolic extract of Benincasa hispida can be a useful memory restorative agent in the treatment of dementia.]]>Mesulam, M.M.,20002nd Edn.,Pages: 574Pages: 574Hebert, L.E., P.A. Scherr, J.L. Bienias, D.A. Bennett and D.A. Evans,20036011191122Shaji, S., S. Bose and A. Verghese,2005186136140Newman, M.F., J.L. Kirchner, B. Phillips-Bute, V. Gaver and H. Grocott et al.,2001344395402Petersen, R.C., R.G. Thomas, M. Grundman, D. Bennett and R. Doody et al.,200535223792388Rogers, S.L., M.R. Farlow, R.S. Doody, R. Mohs, L.T. Friedhoff and Donepezil Study Group,199850136145Reddy, R.S. and S.K. Kulkarni,1998799211227Parle, M. and N. Bansal,20112011Dhingra, D., M. Parle and S.K. Kulkarni,2004Glycyrrhiza glabra in mice.]]>91361365Milind, P. and C. Dev,20123312316Rahman, H., P. Muralidharan, D. Sivaraman and D. Saha,20101185193Pan, J.C. and S.S. Zhang,1996319194Bhattacharya, S.K., S.N. Upadhyay and A.K. Jaiswal,199331822824Clayton, N.S. and J.R. Krebs,19949174107414Kempermann, G., H.G. Kuhn and F.H. Gage,1997386493495Van Praag, H., G. Kempermann and F.H. Gage,19992266270Rhodes, J.S., H. van Praag, S. Jeffrey, I. Girard, G.S. Mitchell, T. Garland Jr. and F.H. Gage,200311710061016Kulkarni, S.K. and D.S. Reddy199618219230Nimbal, S.K., N. Venkatrao, S. Ladde and B. Pujar,2012196101