Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2012.611.616Apium graveolens on Mice and Rats]]>KumarVasanth SultanpurChandrashekhar M. 112012311Stress is defined as a nonspecific response of the body to any excessive demand imposed on it. Stress represents a reaction of the body to a stimulus that tends to alter its normal physiological equilibrium or homeostasis, extreme stress leads to various complications like depression, anxiety, immunosuppressant and endocrine disorder including diabetes mellitus, ulcerative colitis, obesity etc. There is extensive search for plant products for use in stress condition which is devoid of adverse effects. This study was planned to investigate the adaptogenic activity (antistress) of the ethanolic and aqueous extracts of Apium graveolens at various dose using experimentally induced stress models in mice and rats like anoxia stress tolerance, swimming endurance and cold stress model were used for evaluation of adaptogenic activity. Withania sominifera (100 mg kg-1, p.o.) was used as reference standard and it showed significant adaptogenic activity in all three models of stress. The aqueous (200 mg kg-1) and ethanolic (400 mg kg-1) extracts concomitant administration have shown increase in anoxia stress tolarance time and swimming endurance time as compared to control group and also there was marked decrease in blood glucose, cholesterol, triglycerides and BUN level as compare to stress control group in cold stress model. The liver and adrenal gland weight were markedly decreased but no weight change was observed in spleen and testes in this model. The presents study suggests that ethanolic extract of Apium graveolens possess more adaptogenic property than aqueous extracts.]]>Rai, D., G. Goutam, G. Patil, R. Pal, S. Singh and H.K. Singh,2003Bacopa monniera (Brahmi).]]>75823830Singh, A.K., S.S. Dhamanigi and M. Asad,2009Eugenia caryophyllus buds clove.]]>412831Gupta, S., T.G. Ray and I. Saha,200934255257Torres, S.J. and C.A. Nowson,200723887894De Vriendt, T., L.A. Moreno and S. De Henauw,200919511519Wolf, A.M. and G.A. Colditz,1998697106Liu, R., J.Z. Zhang, W.C. Liu, Y. Kimura and Y.N. Zheng,2010Panax quinquefolius L.) in mice fed with a high-fat diet.]]>8110791087Sarah, H.B., B. Robert and J.B. Clifford,20004321327Nocerino, E., M. Amato and A.A. Izzo,200071S1S5Singh, A. and S.S. Handa,1995Apium graveolens and Hygrophila auriculata against paracetamol and thioacetamide intoxification in rats.]]>49119126Tsi, D. and B.K.H. Tan,200066755767Momin, R.A. and G. Nair,2001Apium graveolens L. seeds.]]>49142145Momin, R.A. and M.G. Nair,2002Apium graveolens L. seed.]]>9312318Lewis, D.A., S.M. Tharib, G. Bryan and A. Veitch,1985Apium graveolens L. (Fam. Umbelliferae).]]>232732Guevara, A.P., C. Vargas, H. Sakurai, Y. Fujiwara and K. Hashimoto et al.,1999Moringa oleifera Lam.]]>440181188Liu, W., Y. Zheng, L. Han, H. Wang and M. Saito et al.,2008Panax quinquefolium prevented high-fat diet-induced obesity in mice.]]>1511401145Hu, J.N., X.M. Zhu, L.K. Han, M. Saito and Y.S. Sun et al.,2008Aesculus turbinata BLUME (Hippocastanaceae).]]>561216Klein, G., J. Kim, K. Himmeldirk, Y. Cao and X. Chen,2007Lagerstroemia speciosa.]]>4401407Rangari, V.,2002pp: 130-134pp: 130-134Friedewald, W.T., R.I. Levy and D.S. Fredrickson,197218499502Bhatwadikar, A.D., S.D. Chintawon, R.S. Somani, V.S. Kasture and S.B. Kasture,199931153155Patil, R.A., S.C. Jagdale and S.B. Kasture,2006Rubia cordifolia Linn.]]>44987992Kaur, G. and S.K. Kulkarni,200139551557Han, L.K., Y.N. Zheng, M. Yoshikawa, H. Okuda and Y. Kimura,2005Panax japonicus rhizomes.]]>2005