Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2012.598.604Datura stramonium in Female Rats]]>MahdebN. BouzidiA. KaraN. BenouadahZ. SoufaneS. 112012311The effects of acute, subacute administration of alkaloids
atropine and scopolamine, the main constituents of the active principle of Datura
stramonium, with toxic properties, were studied in female Albino-Wistar
rats. After acute intraperitoneal administration of dose 100 mg kg-1
(≈1/4 DL50) of total alkaloids to the seeds of D. stramonium,
there were no remarkable changes in general appearance and no deaths occurred
in any experimental group. After 24 h a significant reduction was observed in
total alkaloids of seeds. The Red Blood Cells (RBC), Hematocrit (HCT) and Hemoglobin
(HGB) did not show significant changes in the treated groups. There were no
statistical differences in Glutamic-Oxaloacetic Transaminase (GOT), Glutamic-pyruvic
Transaminase (GPT) and Alkaline Phosphatase (ALP) observed between groups. Histological
examination of liver showed no histopathological changes. Subacute study for
four weeks showed no resulting mortality or signs of toxicity. The body gain
and relative weight of organs showed no significant changes. These doses of
synthetic alkaloids (5.2 mg kg-1 of atropine and 2.6 mg kg-1
of scopolamine) did not produce significant changes of hematological parameters
(RBC, HBG and HCT) and biochemical (GPT, GOT and ALP) in comparison with the
control group. Alkaloids of D. stramonium showed no significant toxicity
in female rats.]]>Adekomi, D.A., A.A. Musa, A.A. Tijani, T.D. Adeniyi and B. Usman,2011Datura stramonium Some of its effects on the heart, liver, lungs, kidneys and testes of males sprague dawley rats.]]>36775Antov, G., C. Zaikov, A. Bouzidi, S. Mitova, A. Michaelova, J. Halkova and N. Choumkov,199111349356Aroukou, H., M.D. Matray, C. Braganca, J.P. Mpaka and L. Chinello et al.,2003Datura stramonium Another cause of hospitalization in youth seeking strong sensations.]]>1541S461S50Berny, P., F. Caloni, S. Croubels, M. Sachana, V. Vandenbroucke, F. Davanzo and R. Guitart,2010183255259Birmes, P., V. Chounet, M. Mazerolles, B. Cathala, L. Schmitt and D. Lauque,2002Daturas tramonium: 3 case report.]]>306972Botha, C.J. and M.L. Penrith,2009806374Bouzidi, A., N. Mahdeb and N. Kara,2011Datura stramonium and synthesis alkaloids in male rats.]]>534213431Bouzidi, A., N. Mahdeb, L. Allouche and B. Houcher,200218510 (In French)Bouziri, A., A. Hamdi, A. Borgi, S.B. Hadj, Z. Fitouri, K. Menif and N.B. Jaballah,2011Datura stramonium L. poisoning in a geophagous child: A case report.]]>2011Bruneton, J.,1999Pages: 1120 (In French)Pages: 1120 (In French)Chan, K.,200262830Desachy, A., B. Frois, P. Vignon, J. Roustan and R. Gay,1997Daturas tramonium: Two case reports.]]>65153Dugan, G.M., M.R. Gumbmannand and M. Friedman,1989Datura stramonium) seed.]]>27501510El Hilaly, J., Z.H. Israili and B. Lyoussi,2004Ajuga iva in experimental animals.]]>914350Forrester, M.B., 2006Datura stramonium) exposures in Texas, 1998-2004.]]>6917571762Friedman, M.,2004Solanum tuberosum), tomatoes (Lycopersicon esculentum) and jimson weed (Datura stramonium) seeds.]]>1054143155Gidado, A., A.A. Zainab, M.U. Hadiza, D.P. Serah, H.Y. Anas and M.A. Milala,2007Daturas tramoniumin rats.]]>610121015Guitart, R., S. Croubels, F. Caloni, M. Sachana, F. Davanzo, V. Vandenbroucke and P. Berny,2010183249254Hardman, J.G., L.E. Limbird, P.B. Molinoff, R.W. Ruddon and A.G. Gilman,19989th Edn.,Kara, N., A. Bouzidi, N. Mahdeb and F. Djellal,2009Datura stramonium dans la region de Setif, Algerie.]]>2009Kirchhoff, C., Y. Bitar, S. Ebel and U. Holzgrabe,20041046115120Kumar, G., G.S. Banu, P.V. Pappa, M. Sundararajan and M.R. Pandian, 2004Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats.]]>923740Maruo, V.M., M.M. Bernardi and H.S. Spinosa,2003Solanumly cocarpum St. Hill fruits in male and female adults rats.]]>104852Miraldi, E., A. Masti, S. Ferri and I.B. Comparini,2001Datura stramonium.]]>72644648Naude, T.W., R. Gerber, R.J. Smith and C.J. Botha,200576107112Nelson, P.D., H.D. Mercer, H.W. Essig and J.P. Minyard,198224321325Parrott, A.C.,19861109115Pretorius, E. and J. Marx, 2006Datura stramonium treatment and possible effects on prenataldevelopment.]]>2331337Rodgers, G.C. and R.L. Von Kanel,1993353233Sever, M. and M. Ceken,2007Datura stramonium: Three pediatric cases.]]>52830Stevens, K.R. and M.A. Gallo,19891989Szymanowicz, A. and V. Danel,200520144160Tostes, R.A.,2002Datura stramonium poisoning in a dog.]]>443334Udem, S.C., O. Obidoa and I.U. Asuzu,2010Erythrina senegalensis DC stem bark extract in mice.]]>19275282