Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2012.362.370PatelAmit M. ModiAshish J. PatelGirish N. 9201239This review describes our recent efforts to focus on important function of intelligent polymeric micelles from different block copolymers as novel carrier for delivery of most anticancer drugs and nucleic acids. The polymeric micelles feature a spherical sub-100 nm core-shell structure in which anticancer drugs are loaded avoiding undesirable interactions in vivo. Chemical modification allows the polymeric micelles to release drugs selectively according to the type of chemical modification and nature of polymers. Installation of folic acids on the micelle surface improves cancer cell-specific drug delivery efficiency along with pH controlled drug release. These intelligent micelles appear to be superior over classical micelles that physically incorporate drugs. Studies showed both controlled drug release and targeted delivery features of the micelles reduced toxicity and improved efficacy significantly. Further developments potentiate combination delivery of multiple drugs using mixed micelles. Micelle-forming block copolymer-drug conjugates, micellar nanocontainers and polyion complex micelles have been obtained that mimic functional aspects of biological carriers, namely, lipoproteins and viruses. Therefore, clinically relevant performance of the polymeric micelles provides a promising approach for more efficient and patient-friendly cancer therapy. Intelligent polymeric micelles may be advantageous in terms of safety, stability and scale-up.]]>Peppas, N.A., J.Z. Hilt, A. Khademhosseini and R. Langer,20061813451360Kataoka, K., A. Harada and Y. Nagasaki,200147113131Chu, B.,199511414421Holland, R.J., E.J. Parker, K. Guiney and F.R. Zeld,1995991198111988Moffitt, M., K. Khougaz and A. Eisenberg,19962995102Alexandridis, P. and L. Yang,20003333823391Price, C.,19835515631572Quintana, J.R., M. Villacampa and I.A. Katime,199326601605Quintana, J.R., M. Villacampa and I.A. Katime,19933423802385Triolo, F., A. Triolo, R. Triolo, J. D. Londono and G. D. Wignall et al.,200016416421Triolo, F., A. Triolo, R. Triolo, D.C. Streytler and C.A. Lewis et al.,20006146404643Allen, C., D. Maysinger and A. Eisenberg,199916327Nishiyama, N., Y. Bae, K. Miyata, S. Fukushima and K. Kataoka,200522126