Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2012.144.149Toddalia asiatica (L.) Lam. using Different Experimental Models]]>BalasubramaniamA. ManivannanR. ParamaguruR. MazumderPapiya MitraVijayakumarM. 5201235Background: This study was designed to investigate the anti-inflammatory and free radical scavenging potential of 50% ethanolic extract of stem bark of Toddalia asiatica (L.) Lam. Materals and Methods: The anti-inflammatory activity of 100, 200, 400 mg kg-1 of 50% ethanolic extract of stem bark of Toddalia asiatica was assessed by Carrageenan-induced rat paw edema method and Cotton pellet granuloma method. The antioxidant activity of the same was assessed by Free radical scavenging activity using 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), Nitric oxide scavenging activity, Hydroxyl radical scavenging activity and Chelation of Ferrous (Fe2+) ions. Results: All the three doses (100, 200, 400 mg kg-1) of the extract showed reduction in paw volume from first hour to third hour significantly. The extract at a dose of 400 mg kg-1 p.o. of the extract showed the maximum value 44.37% of anti-inflammatory activity. The 100, 200, 400 mg kg-1 p.o. of the extract significantly (p<0.01) reduced the granuloma dry weight when compared to the control. Toddalia asiatica showed good radical scavenging activity at various concentrations (200-1000 μg mL-1) against DPPH with IC50 value of 240.07 μg mL-1, OH radical with IC50 value of 432.17 μg mL-1, NO radical with IC50 value of 324.81 μg mL-1 and the same showed moderate scavenging activity against Chelation of Fe2+ ions with IC50 value of 483.21 μg mL-1. Conclusion: Present study indicates that 50% ethanolic extract of stem bark of Toddalia asiatica (L.) Lam possessed effective anti inflammatory and antioxidant activity.]]>Blois, M.S.,195818111991200Boughton-Smith, N.K., A.M. Deakin, R.L. Follenfant, B.J.R. Whittle and L.G. Coarland,1993110896902Chawla, A.S., B.S. Kaith, S.S.Handa, A.K.Sharma and S.K. Balbir,198746214223Conner, E.M. and M.B. Grisham,199612274277Di Rosa, M.,19695315331539Diener, W., U. Mischke, D. Kayser and E. Schlede,199569729734Duraipandiyan, V. and S. Ignacimuthu,2009Toddalia asiatica (L.) Lam.]]>123494498El-Shenawy, S.M., O.M. Abdel-Salam, A.R. Baiuomy, S. El-Baeran and M.S. Arbid,200246235243Fernandez, M.A., B. de las Heras, M.D. Garcia, MT. Saenz and A. Villar,20015315331539Garcia, L.J., L. Nakamura, M.P. Leite and M. Rocha e Silva,1973488896Govindarajan, R., M. Vijayakumar, C.V. Rao, A. Shirwaikar, A.K. Rawat, S. Mehrotra and P. Pushpangadan,2003Anogeissus latifolia.]]>2712661269Grisham, M.B.,19921992pp: 39pp: 39Iwasaki, H., T. Okabe, K. Takara, T. Toda, M. Shimatani and H. Oku,2010Toddalia asiatica (L.) Lam.]]>65719726Korhonen, R., A. Lahit, H. Kankaanranta and E. Moilanen,20054471479Kuo, S.M., P.S. Leavitt and C.P. Lin,199863135153Lu, S.Y., Y.J. Qiao, P.G. Xiao and X.H. Tan,2005Toddalia asiatica (L.) against influenza type A virus.]]>309981001Meier, R., W. Schuller and P. Desaulles,1950Andrographis echioides nees.]]>69469471Muregi, F.W., A. Ishih, T. Miyase, T. Suzuki and H. Kino et al.,2007111190195Nagarajan, N.S., V. Nandagopalan, R. Senthamoral, J.M. Christiana and A.M. Ismail,2005Dalhergia malabarcia (prain).]]>64549Nash, T.,195355416421Pawar, C.R., V.S. Gulecha, M. Mohan, V.S. Kasture and S.C. Pal,2008Caesalpinia pulcherrima (Caesalpiniceae).]]>87275Rice-Evans, C.A. and N.J. Miller,199624790795Salvemini, D. and J.L. Masferrer,1996In vitro, ex vitro and in vivo studies.]]>2691225Sreejayan, D. and M.N.A. Rao,199749105107Sreelekshmi, R., P.G. Latha, M.M. Arafat, S. Shyamal and V.J. Shine et al.,2007Ficus religiosa Linn.]]>6377381Tatiya, A.U., A.K. Saluja and S.J. Surana,200881823Vane, J.R. and R.M. Botting,1995234148Vinegar, R., W. Schreiber and R. Hugo,196916696103Vogel, H.G., 2002pp: 401pp: 401Winter, C.A., E.A. Risley and G.W. Nuss,196211544547Yesilada, E., O. Ustun, E. Sezik, Y. Takaishi, Y. Ono and G. Honda,1997585973