Pharmacologia2044-46482044-4656Science International10.3923/pharmacologia.2012.138.143Murraya paniculata]]>ParamaguruR. JanakiP. SilambuEswaranM. Bavani RaoCh.V. RawatA.K.S. VijayakumarM. 5201235Background: The high antioxidant activity compounds derived from plants are paramount demand for the pharmaceutical, food industries, mitigating their use as replacements for synthetic antioxidants which are playing significant role in preventing many diseases. This research study was designed to investigate the free radical scavenging and lipid peroxidation inhibition potential of 50% ethanolic extract of leaves of Murraya paniculata (MPET) and its various fractions of hexane (MPHF), chloroform (MPCF), ethyl acetate (MPEF) and methanol (MPMF). Materials and Methods: The free radical-scavenging potential of all fractions of Murraya paniculata extract were determined by β-carotene bleaching assay, 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, Nitric oxide (NO), Hydroxyl radical (OH) and ferryl bipyridyl complex scavenging activity. Similarly, Lipid Peroxidation inhibition (LPO) using Thiobarbituric Acid Reactive Substances (TBARS) in rat liver homogenate and total antioxidant capacity. In addition to that integral anti oxidative capacity was studied by Photochemiluminescence assay (PCL). Results: In β-carotene bleaching assay, MPEF showed acme percentage of antioxidant activity, MPET showed moderate percentage of antioxidant activity, good radical scavenging activity at various concentrations (200-1000 μg mL-1) against DPPH and the same showed modest scavenging activity against NO, OH, ferryl bipyridal complex and LPO inhibition. Further among the fractions, MPEF showed potent scavenging activity against DPPH, NO, OH, ferryl bipyridal complex and LPO Inhibition. MPMF showed moderate scavenging activity against DPPH, OH, NO Radicals. Conclusion: The 50% ethanolic extract of leaves of Murraya paniculata and its ethyl acetate fraction (MPEF) were very effective antioxidants.]]>Ali, S.S., N. Kasoju, A. Luthra, A. Singh, H. Sharanabasava, A. Sahu and U. Bora,200841115Bhattacharya, S.K., K.S. Satyan and S. Ghosal,1997Withania somnifera.]]>35236239Blois, M.S.,195818111991200Desmarchelier, C., R.L. Romao, J. Coussio and G. Ciccia,1999676977Dringen, R.,200026749034918Emmons, G.L. and D.M. Peterson,199976902906Finkel, T. and N.J. Holbrook,2000408239247Govindarajan, R., M. Vijaykumar, C.V. Rao, A. Shirwaikar, A.K.S. Rawat, S. Mehrotra and P. Pushpangadan,2004Anogeissus latifolia.]]>2712661269Govindarajan, R., M. Vijayakumar, C.V. Rao, V. Kumar, A.K.S. Rawat and P. Pushpangadan,2004Asparagus racimosus against streptozotocin-induced oxidative stress.]]>101771781Gutteridge, J.M.C.,1985834144148Halliwell, B. and J.M.C. Gutteridge,19891989pp: 416-508pp: 416-508Halliwell, B.,197892321326Ilavarasan, R., S. Mohideen, M. Vijayalakshmi and G. Manonmani,2001Cassia angustifolia Vahl.]]>63504507Jha, P., M. Flather, E. Lonn, M. Farkouh and S. Yusuf,1995123860872Kinoshita, T. and K. Firman,1996Murraya paniculata.]]>4212071210Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.I. Randall,1951193438448Manonmani, G., K. Anbarasi, K. Balakrishna, G. Veluchamy and C.S. Shyamala Devi,2002Terminalia arjuna on the antioxidant defense system in alloxan induced diabetes in rats.]]>225261Maritim, A.C., R.A. Sanders and J.B. Watkins III,2003172438Miller, N.J., C. Rice-Evans, M.J. Davies, V. Gopinathan and A. Milner,199384407412Nash, T.,195355416421Ohkawa, H., N. Ohishi and K. Yagi,197995351358Parrotta, J.A.,2001Pages: 917Pages: 917Ragazzi, E. and G. Veronese,197377369375Ramakrishna, B.S., R. Varghese, S. Jayakumar, M. Mathan and K.A. Balasubramanian,199712490494Saxena, A.K., P. Srivastava, R.K. Kale and N.Z. Baquer,199345539542Schulz, J.B., J. Lindenau, J. Seyfried and J. Dichgans,200026749044911Singh, R.P., K.N.C. Murthy and G.K. Jayaprakasha,2002Punica granatum) peel and seed extracts using in vitro models.]]>508186Sreejayan, D. and M.N.A. Rao,199749105107Tang, L.Q., W. Wei, L.M. Chen and S. Liu2006108109115Tripathi, Y.B. and M. Sharma,1998Rubia cordifolia with rubiadin.]]>35313316Valentao, P., E. Fernandes, F. Carvalho, P.B. Andrade, R.M. Seabra and M.D.L. Bastos,2002Hypericum androsaemum infusion: Scavenging activity against superoxide radical, hydroxyl radical and hypochlorous acid.]]>2213201323Valko, M., C.J. Rhodes, J. Moncol, M. Izakovic and M. Mazur,2006160140Vijayakumar, M., R. Govindarajan, G.M. Rao, C.V. Rao, A. Shirwaikar, S. Mehrotra and P. Pushpangadan,2006Hygrophila auriculata against streptozotocin-induced oxidative stress.]]>104356361Vijayakumar, M., R. Govindarajan, G.M. Rao, Ch.V. Rao, A. Shirwaikar, S. Mehrotra and P. Pushpangadan,2005Hygrophila auriculata.]]>112226