Kidney Research Journal1819-33742154-3836Academic Journals Inc.10.3923/krj.2015.1.4GuptaPunit DubeyPrachi KhuntePrakash GuptaG.B. 1201551A total number of 86 patients of 15-38 year age group were taken, Out of which,
30 were males (34.88%) and 56 were females (65.11%). The mean age of population
was 26±11.6 year. These all patients were suffered from sickle cell nephropathy.
All patient were subjected to renal function test, Hb electrophoresis and all
routine investigations in form of blood glucose urine analysis, lipid profile
serum protein 24 h, urine protein, chest X-ray. In this study, it was found
that the incidence of infection is more common in female i.e., 70% of total
patients. The 81.08% patients having sickle cell nephropathy suffered from urinary
tract infection, 66.66% patients of sickle cell nephropathy had pyuria and 13.33%
patients show lung infection in form of consolidation and pleural effusion.
Among patients suffered from urinary tract infection, 38.23% patients had proteinuria
<1 g/24 h and 61.76% patients have proteinuria >1 g/24 h, that proved
the glomerular involvement in sickle cell nephropathy. Hypothyroidism seen in
18.18% patients having infection as compared to 11.11% patients without in infection.
Thus, this study has shown that sickle cell nephropathy manifestated more common
in form of proteinuria and infection (urinary tract and lung infection).]]>Bunn, H.F.,1997337762769Kaul, D.K., M.E. Fabry, F. Costantini, E.M. Rubin and R.L. Nagel,1995In vivo demonstration of red cell-endothelial interaction, sickling and altered microvascular response to oxygen in the sickle transgenic mouse.]]>9628452853Bruno, D., D.R. Wigfall, S.A. Zimmerman, P.M. Rosoff and J.S. Wiener,2001166803811Powars, D.R., D.D. Elliott-Mills, L. Chan, J. Niland, A.L. Hiti, L.M. Opas and C. Johnson,1991115614620Powars, D.R., L.S. Chan, A. Hiti, E. Ramicone and C. Johnson,200584363376Hakimi, A.A., P.T. Koi, P.M. Milhoua, N.M. Blitman and M. Li et al.,200770878882McCall, I.W., N. Moule, P. Desai and G.R. Serjeant,197812699104Sesso, R., M.A. Almeida, M.S. Figueiredo and J.O. Bordin,19983112571262Serjeant, G.R., C.D. Ceulaer, R. Lethbridge, J. Morris, A. Singhal and P.W. Thomas,199487586591Lobel, J.S. and K.E. Bove,1982136543547Zarkowsky, H.S., D. Gallagher, F.M. Gill, W.C. Wang and J.M. Falletta et al.,1986109579585