Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2023.76.82OdingaT. ToghiB.R. GoldenS.N. Austin-AsomejiI. LemiiB.C. 22023182Background and Objective: Diarrhea is a condition of the bowel, consisting of frequent watery stool. Various treatments have been employed in treating this condition but pose certain side effects. This study was designed to investigate and compare the anti-diarrhea potencies of coconut water and palm kernel oil. Materials and Methods: Albino rats (42) were used for this study. They were divided into 2 groups of 21 rats each, then a sub-group of 7 with 3 rats each. All rats were allowed to acclimatize for 14 days with access to food and water ad libitum. Group A rats were the castor oil-induced diarrhea test group while group B was the gastrointestinal testing group. After the experimental procedures, the rats were sacrificed and blood samples were collected for serum electrolyte analysis. Small intestines were identified and the total length of intestines and distance travelled by charcoal meal were measured for calculation of intestinal propulsion. Results: The results obtained showed that treatment with coconut water and kernel oil reduced the frequency and subsequently the soft and watery consistency of the stool significantly at p<0.05. Coconut water and palm kernel oil stimulated a significant reduction at p<0.05 in the propulsion of the charcoal meal at both concentrations. Coconut water and palm kernel oil inhibited diarrhea by reducing stool frequency and inhibited intestinal propulsion as well as electrolyte loss. Conclusion: The results obtained suggested that coconut water restored lost electrolytes during diarrhea, whereas palm kernel oil at low doses showed the potency of curbing diarrhea.]]>Odinga, T., E.B. Essien and J.O. Akaninwor,2018Ricinodendron heudelotii seeds against aspirin-induced ulcer.]]>4663669Odinga, T., E.B. Essien and J.O. Akaninwor,2020Ricinodendron heudelotii in Wistar albino rats.]]>13341345Talbert, A., N. Thuo, J. Karisa, C. Chesaro and E. Ohuma et al.,20122012Faure, C.,20132013Eyres, L., M.F. Eyres, A. Chisholm and R.C. Brown,201674267280Mohammed, A. and C.D. Luka,201365659Tan, C.P. and Y.B.C. Man,200077143155Atasie, V.N. and T.F. Akinhanmi,20098800803Ugbogu, O.C., R.A. Onyeagba and O.A. Chigbu, 2006Candida albicans.]]>510451047Olaniyi, A.P., O.O. Babalola and O.A. Mary,20146205207Patel, V.R., G.G. Dumancas, L.C.K. Viswanath, R. Maples and B.J.J. Subong,20162016Tunaru, S., T.F. Althoff, R.M. Nüsing, M. Diener and S. Offermanns,20123 receptors.]]>10991799184Gangwara, A.S., A. Bhardwaja and V. Sharma,2018Bacillus coagulans.]]>7100110Adeniyi, O.S., M. Edache, I. Abi and R.J. Ediale,20203309315NRC,20118th Edn.,Pages: 246Pages: 246Edem, G.D., E.B. Etuk and A.O. Igiri,201618113Liu, L and I.M. Coupar,1997Alpha-2 adrenoceptors in the effects of moxonidine on intestinal motility and fluid transport.]]>28313671374DebMandal, M. and S. Mandal,2011Cocos nucifera L.: Arecaceae): In health promotion and disease prevention.]]>4241247Silalahi, J., Rosidah, E.D.L. Putra and D. Satria,20168182186de Queiroz Leite, M.E., J. Lasekan, G. Baggs, T. Ribeiro and J. Menezes-Filho et al.,20132013Tagne, M.A.F., H. Akaou, P.A. Noubissi, A.F. Fondjo and Y. Rékabi et al.,2019Bixa orellana Linn (Bixaceae) leaves on castor oil-induced diarrhea in swiss albino mice.]]>2019Yong, J.W.H., L. Ge, Y.F. Ng and S.N. Tan,2009Cocos nucifera L.) water.]]>1451445164Segura-Badilla, O., M. Lazcano-Hernández, A. Kammar-García, O. Vera-López, P. Aguilar-Alonso, J. Ramírez-Calixto and A.R. Navarro-Cruz,2020Cocus nucifera L) for the development of a symbiotic functional drink.]]>2020Campbell-Falck, D., T. Thomas, T.M. Falck, N. Tutuo and K. Clem,200018108111Ismail, I., R. Singh and R.G. Sirisinghe,200738769785Kalman, D.S., S. Feldman, D.R. Krieger and R.J. Bloomer,20122012Bayorh, M.A., I.K. Abukhalaf and A.A. Ganafa,200514325339Odinga, T., C. Gabriel-Brisibe and B.W. Moore-Igwe,2020Ricinodendron heudelotii on the blood electrolyte and hematological status of male Wistar albino rats.]]>61620Odinga, T. and C.O. Odu,20183161172