Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2022.43.49Staphylococcus aureus producing Penicillinase from Health Workers]]>IyevhobuK.O. AllehA.O. AirefetalorA.I. OsagiedeE.K. IkedeR.E. BabatopeI.O. EdoE.O. Ozurumba-DwightL.N. 12022171Background and Objective: Methicillin-Resistance Staphylococcus aureus (MRSA) usually colonizes the skin, respiratory tract and urinary tract. MRSA is considered an emerging disease because it’s easily communicated from one person to another and its incidence is rising quickly. This study was undertaken to evaluate the carrier of methicillin resistance/sensitive Staphylococcus aureus producing penicillinase from health workers. Materials and Methods: Specimens were collected randomly from the health workers with a sterile swab stick from the nasal nares (nasal swab), skin swab and swab from the laboratory coat of workers (practitioners) in Irrua Specialist Teaching Hospital (ISTH), Irrua, Edo State, Nigeria. A total of 200 specimens (nasal swab, skin swab and laboratory coat swab) were randomly collected from apparently healthy male and female subjects. Results: This study, had 30 (15%) Staphylococcus aureus prevalence with the highest occurrence of 24 (30%) from skin swabs and 6 (7.5%) from nasal swabs. About 13 (43.3%) prevalence of MRSA was recorded with the highest occurrence seen in skin 9 (30%), 4 (13.3%) from nasal swabs while 17 (56.6%) of the Staphylococcus aureus isolates were Methicillin-Sensitive (MSSA). When the prevalence of MRSA and MSSA were analyzed, 7 (23%) were penicillinase negative (non-producing) and there was no significant difference. About 23 (77%) penicillinase-producing Staphylococcus aureus, 13 (57%) were methicillin/resistant and 10 (43%) were methicillin/sensitive Staphylococcus aureus with no significant difference between the two growth from penicillinase-producing. Conclusion: It was observed that methicillin-resistant/penicillinase-producing Staphylococcus aureus is significantly present in the skin and nasal nares of staff in ISTH and this may pose nosocomial infection prevalent in the hospital environment if not promptly detected and controlled.]]>Baddour, L.M., W.R. Wilson, A.S. Bayer, V.G. Fowler and I.M. Tleyjeh et al.,201513214351486Iwase, T., Y. Uehara, H. Shinji, A. Tajima and H. Seo et al.,2010Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization.]]>465346349Blot, S.I., K.H. Vandewoude, E.A. Hoste and F.A. Colardyn, 2002Staphylococcus aureus.]]>16222292235Iyevhobu, K.O., A.R.M. Momoh, J. Etafo, A.I. Airefetalor and E.K. Osagiede,2022Staphylococcus aureus in nasal and skin of apparently healthy food handlers and attendants in restaurants.]]>2022Liu, G.Y., A. Essex, J.T. Buchanan, V. Datta and H.M. Hoffman et al.,2005Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity.]]>202209215Lena, P., S.A. Karageorgos, P. Loutsiou, A. Poupazi, D. Lamnisos, P. Papageorgis and C. Tsioutis,20222022Francois, P. and J. Schrenzel,2008Staphylococcus aureus.]]>2008Iyevhobu, K.O., 20212021Foley, J.M. and C.J. Perret,1962195287288Solomon, A., I.O. Kenneth, O. Marcus, O.B. Nnaemeka and E. Maxwel,2018Staphylococcus aureus in clinical samples and fomites.]]>7244255Unni, S., T.J. Siddiqui and S. Bidaisee,2021Staphylococcus aureus: A review of global incidence patterns and related genetic mechanisms.]]>2021Sing, A., C. Tuschak and S. Hörmansdorfer,2008Staphylococcus aureus in a family and its pet cat.]]>35812001201Gupta, A.K., D.C.A. Lyons and T. Rosen,2015Staphylococcus aureus infections.]]>5412261232David, M.Z. and R.S. Daum,2010Staphylococcus aureus: Epidemiology and clinical consequences of an emerging epidemic.]]>23616687Qian, M., S. Tang, C. Wu, Y. Wang, T. He, T. Chen and X. Xiao,2015Staphylococcus aureus.]]>305501504Rawat, V., M. Singhai and P.K. Verma,2013Enterobacteriaceae and Pseudomonas spp.]]>52125Taiwo, S.S., B.A. Onile and A.A. Akanbi,2004Staphylococcus aureus (MRSA) in Ilorin Nigeria.]]>5189197Harkins, C.P., B. Pichon, M. Doumith, J. Parkhill and H. Westh et al.,2017Staphylococcus aureus emerged long before the introduction of methicillin into clinical practice.]]>2017