Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2020.16.21Ficus sur Leaves on Diethylnitrosamine-induced Toxicity in Wistar Rats]]>YakubuOjochenemi Ejeh OjogbaneEleojo AbuMichael Sunday ShaibuChristopher O. AyegbaWinner Emmanuel 12020151Background and Objective: Many plant materials used in traditional medicine are readily available in rural areas and have made folklore medicine relatively cheaper than modern medicine. The significance of this study was to investigate the hematinic effect of the ethanol extract of Ficus sur leaves on diethyl nitrosamine induced haemolytic anaemia in Wistar rats. Materials and Methods: The leaves of Ficus sur plant were collected within the premises of Federal University Wukari, Taraba State. Twenty five Wistar rats of 100-150 g were acquired and transported to the animal house of the Department of Biochemistry, Federal University Wukari. The rats were grouped into 4 groups of 5 rats each. Group A served as the normal control and received no induction nor treatment, group B were induced with single dose 200 mg kg1/i.v diethyl nitrosamine but not treated while group C and D were induced with single dose 200 mg kg1/i.v body weight diethyl nitrosamine and subsequently treated with 200 mg kg1/p.o/daily of ethanolic extract of Ficus sur leaves and 50 mg kg1/p.o/daily silymarin (standard drug), respectively for a period of 21 days. Results: The results showed that administration of diethyl nitrosamine significantly decrease (p<0.05) RBC, HGB, HCT, MCV, MCH, MCHC and PLT levels as compared to the normal control and significantly increase (p<0.05) WBC, RDWc, MID, GRA and LYM. In the other hand, administration of ethanolic extract of Ficus sur leaves and silymarin ameliorated these haematological indices near normal levels. Conclusion: The results of this investigation was an indication of a possible ameliorative effect of ethanolic extract of Ficus sur leaves against diethyl nitrosamine induced haematotoxicity in wistar rats and may be a confirmation of the traditional use of this plant as blood enhancer.]]>Adebayo, M.A., S.S. Enitan, W.M. Owonikoko, E. Igogo and K.O. Ajeigbe,2017208592N'Guessan, K., K.H. Kouassi and D. Ouattara,2010612912197Adebayo-Tayo, B.C. and A.O. Odeniyi,2012153540Ahrens, W., H. Pohlabeln, R. Foraita, M. Nelis and P. Lagiou et al.,201450616625Ahmadua, A.A., A.U. Zezi and A.H. Yaro,2007Daniellia oliveri hutch and Dalz (Fabaceae) and ficus sycomorus Miq (Moraceae).]]>4524528Saloufou, K.I., P. Boyode, O. Simalou, K. Eloh and K. Idoh et al.,2018Ficus sur.]]>7185192Nadel, H., J.H. Frank and R.J. Knight,1992752938Kaur, A., A.C. Rana, V. Tiwari, R. Sharma and S. Kumar,2011Ficus religiosa.]]>10611Ojukwu, U.P. and O.F. Ibekwe,2018Ficus sur (Forssk).]]>53544Imo, C., O.E. Yakubu, N.G. Imo, I.S. Udegbunam, S.V. Tatah and O.J. Onukwugha,2018Piper guineense seeds and leaves.]]>18329337Yakubu, O.E., O.F.C. Nwodo, S.M.C. Udeh and M. Abdulrahman,2016Vitex doniana leaf on postprandial blood sugar concentration in wister rats.]]>1117Atawodi, S.E.O., O.E. Yakubu, M.L. Liman and D.U. Iliemene,2014Tetrapleura tetraptera (Schum and Thonn) Taub leaves on hyperglycemia and indices of diabetic complications in alloxan-induced diabetic rats.]]>4272278Yakubu, O.E., E. Ojogbane, O.F.C. Nwodo, V.O. Nwaneri-Chidozie and K. Dasofunjo,2013Vitex doniana on streptozotocin-induced diabetes in albino rats.]]>1259335940Osigwe, C.C., P.A. Akah and C.S. Nworu,2017Newbouldia laevis in alloxan-induced diabetic rats.]]>51836Afolabi, K.D., A.O. Akinsoyinu, R. Olajide and S.B. Akinleye,20102010pp: 347349Rajendran, V. and K. Krishnaswamy,2017Solanum villosum (Mill.) Extract and its silver nanoparticles on hematopoietic system of diethylnitrosamine-induced Hepatocellular Carcinoma in rats.]]>51316Brian, I.C.,20163rd Edn., Mansi, K. and J. Lahham,2008Artemisia sieberi besser (A. herba-alba) on heart rate and some hematological values in normal and alloxan-induced diabetic rats.]]>45762Li, S., H.Y. Tan, N. Wang, Z.J. Zhang, L. Lao, C.W. Wong and Y. Feng,2015162608726124Atawodi, S.E., L.M.D. Yusufu, J.C. Atawodi, O. Asuko and O.E. Yakubu,2011Elaeis guineensis). ]]>3153161Shin, S.H., M.K. Ye, H.S. Kim and H.S. Kang,2007718131818Famurewa, A.C., S.C. Kanu, V.N. Ogugua and M.L. Nweke,2015Hibiscus sabdariffa against carbon tetrachloride-induced hematotoxicity.]]>15138143Yakubu, O.E., R.H.N. Boyi, C. Shaibu, M.A. Abah and J. Akighir,2019Hymenocardia acida stem bark ethanolic extract.]]>14263270Gopinath, P., S.K. Gogoi, P. Sanpui, A. Paul, A. Chattopadhyay and S.S. Ghosh,201077240245