Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2017.24.32SwelamEman S. AbdallahIbrahim S. MossaAbdel-Tawab H. 12017121Objective: The present study was carried out to investigate the protective effect of zinc against oxidative damage induced by fipronil (FPN) in the liver and kidney of male rats. Methodology: Rats were assigned to four groups and received, water (control group), fipronil at concentration 10 mg L1 (2.0 mg kg1 b.wt.), zinc at concentration 227 mg L1 and fipronil plus zinc group. All treatments were administered through drinking water for 45 days. The concentration used of fipronil in this study represents 2.0 mg kg1 b.wt., based on average water consumptions and body weights of treated rats. Results: Results revealed that fipronil induced insignificant changes in body weight and significant increase in liver weight of treated rats. Also, significant activities of oxidative stress enzymes such as, superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx), catalase (CAT) and level of glutathione reduced (GSH) were obtained. The FPN caused a significant elevation in lipid peroxidation level. However, the adverse effects induced by FPN were mitigated when the rats were supplemented with zinc. Moreover, three new protein bands were detected only in the electrophoretic pattern of the FPN treated group and disappeared in the remaining three groups; control, zinc and fipronil plus zinc. Conclusion: The overall outcome suggested that FPN induced adverse effects on oxidant/antioxidant status in the liver and kidney of intoxicated rats and zinc has a role in attenuating these effects. These outcome show that administration of Zn may be useful, easy and economical to protect human against phenyl pyrazole insecticide toxic effects.]]>Tingle, C.C.D., J.A. Rother, C.F. Dewhurst, S. Lauer and W.J. King,2003176166Jennings, K.A., T.D. Canerdy, R.J. Keller, B.H. Atieh, R.B. Doss and R.C. Gupta,200244301303Mansour, S.A. and A.T.H. Mossa,2010961423Mossa, A.T.H., T.M. Heikal, M. Belaiba, E.G. Raoelison, H. Ferhout and J. Bouajila,2015Cedrelopsis grevei on cypermethrin induced oxidative stress and liver damage in male mice.]]>2015Badgujar, P.C., G.A. Chandratre, N.N. Pawar, A.G. Telang and N.P. Kurade,20163111471158Assayed, M.E., A.A. Khalaf and H.A. Salem,2010in vivo cypermethrin-induced cytogenetic damage in rat bone-marrow.]]>70217Mossa, A.T.H., A.A. Refaie and A. Ramadan,20115323335Yousef, M.I., F.M. El-Demerdash and K.S. Al-Salhen,200338463478Powell, S.R.,20001301447S1454SParrat, M.O., M.J. Richard, J.C. Beani and A. Favier,199760187204Mossa, A.T.H., E.S. Swelam and S.M.M. Mohafrasha,20152775784Goel, A., V. Dani and D.K. Dhawan,2005156131140Nishikimi, M., N.A. Rao and K. Yagi,197246849854Aebi, H.,1984in vitro.]]>1984pp: 121-126pp: 121-126Habig, W.H., M.J. Pabst and W.B. Jakoby,197424971307139Paglia, D.E. and W.N. Valentine,196770158169Beutler, E., O. Duron and B.M. Kelly,196361882888Satoh, K.,1978903743Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275Laemmli, U.K.,1970227680685Sharma, D. and G.K. Sangha,20141107180Al-Othman, A.M., K.S. Al-Numair, G.E. El-Desoky, K. Yusuf, Z.A. Al Othman, M.A. Aboul-Soud and J.P. Giesy,2011512631271Sayeed, I., S. Parvez, S. Pandey, B. Bin-Hafeez, R. Haque and S. Raisuddin,2003Channa punctatus Bloch.]]>56295301Mossa, A.T.H., F.M. Ibrahim, S.M. Mohafrash, D.H. Abou Baker and S. El Gengaihi,20152015Elgengaihi, S., A.T.H. Mossa, A.A. Refaie and D. Aboubaker,2016Cichorium intybus L. extract against carbon tetrachloride-induced liver damage in rats.]]>13570584Kehrer, J.P.,1993232148Banerjee, B.D., V. Seth, A. Bhattacharya, S.T. Pasha and A.K. Chakraborty,19991073347Tukhtaev, K.R., S.K. Tulemetov, N.B. Zokirova, N.K. Tukhtaev and M.R. Tillabaev et al.,201310111Mansour, S.A. and A.T.H. Mossa,2009933439Mossa, A.T.H., T.M. Heikal, S.M.M. Mohafrash and A.A. Refaie,2015Origanum majorana leaves extract against oxidative damage and hepatotoxicity induced by pirimiphos-methyl in male mice.]]>156979Hayes, J.D. and D.J. Pulford,199530445520Margarido, T.C.S., A.A. Felicio, D.D.C. Rossa-Feres and E.A. de Almeida,2013Scinax fuscovarius tadpoles exposed to a commercial formulation of the pesticide fipronil.]]>916167Mossa, A.T.H., T.M. Heikal and E.A.A. Omara,20144137145Yousef, M.I., T.I. Awad and E.H. Mohamed,2006227240247Fukino, H., M. Hirai, Y.M. Hsueh, S. Moriyasu and Y. Yamane,1986197589Seagrave, J.C., R.A. Tobey and C.E. Hildebrand,19833230173021Prasad, A.S.,19931993pp: 17-53pp: 17-53Prasad, A.S.,200843370377Chavapil, M., J.N. Ryan and C.F. Zukoski,1982141150158Baiomy, A.A., F.H. Attia, M.M. Soliman and O. Makrum,201528122128Radwan, E.M.,2001Eariasinsulana (Boisd).]]>2001Saleem, M.A., A.R. Shakoori and D. Mantle,1998Tribolium castaneum (Herbst.)(Coleoptera: Tenebrionidae).]]>39144154Margoshes, M. and B.L. Vallee,19577948134814Eaton, D.L., N.H. Stacey, K.L.Wong and C.D. Klaassen,198055393402Sharma, R.P. and M.P. Verma,198041548551Onosaka, S. and M.G. Cherian,19812291101Masao, S., O. Atsushi, T. Koichiro, M. Hiroshi and N. Yasushi,1989454147Sayed, M.A.,20012631873202Webb, M. and K. Cain,198231137142Beggel, S., I. Werner, R.E. Connon and J.P. Geist,2012Pimephales promelas) following short-term exposure.]]>426160165