Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2013.42.48Andrographis paniculata and Silybum marianum
on Five Human Cancer Cell Lines]]>SinghS. MehtaA. BawejaS. AhirwalL. MehtaP. 1201381Andrographis paniculata and Silybum marianum are well known medicinal
plants. However, to prove their efficacy for clinical utilization more scientific
data are needed. Therefore, in the present study, an attempt was made to investigate
the anticancer potential of hydroalcoholic extracts of A. paniculata
and S. marianum and their combination (1:1). The sulphorhodamine B (SRB)
assay was used to assess growth inhibition of human tumor. Five human cancer
cell lines i.e., human breast adenocarcinoma (MCF-7), human cervix (SiHa), Colon
(HT-29), Ovary cancer cell line (ovcar-5) and Liver (HepG2) were used for the
above study. The results obtained suggest that S. marianum hydroalcoholic
extract showed the best cytotoxic activity against all given cell lines with
percentage inhibition of 21.34, 32.30, 46.56, 59.58, 36.20 for MCF 7, SiHa,
HT-29, Ovcar-5 and HepG2, respectively. While, A. paniculata hydroalcoholic
extract was found most effective against Ovcar-5 with 51.12% inhibition. The
combination of both the plants (1:1) showed an intermediate result for all the
cell line but, it was found to be most effective against HepG2 with 42.76% inhibition.
The results obtained in the study indicate that A. paniculata and S.
marianum possess significant anticancer activity and have the therapeutic
potential to prevent the cancerous diseases.]]>Trivedi, N.P. and U.M. Rawal,2001Andrographis paniculata (Nees) in BHC induced liver damage in mice.]]>394146Singh, S., A. Mehta, J. John and P. Mehta,2009Andrographis paniculata, Cajanus cajan and Silybum marianum.]]>1243245Caceres, D.D., J.L. Hancke, R.A. Burgos and G.K. Wikman,1997Andrographis paniculata dried extract: A pilot double blind study.]]>4101104Wang, D.W. and H.Y. Zhao,1993Andrographis paniculata nees and fish oil.]]>13193198Puri, A., R. Saxena, R.P. Saxena, K.C. Saxena, V. Srivastav and J.S. Tandon,1993Andrographis paniculata.]]>58995999Fraschini, F., G. Demartini and D. Espostii,2002225165De La Puerta, R., E. Martinez, L. Bravo and M.C. Ahumada,199648968970Katiyar, S.K., N.J. Korman, H. Mukhtar and R. Agarwal,199789556566Lang, I., K. Nekam, R. Gonzalez-Cabello, G. Muzes, P. Gergely and J. Feher,199015123127Monks, A., D. Scudiero, P. Skehan, R. Shoemaker and K. Paull et al.,199183757766Conese, M. and F. Blasi,19958365389Cirla, A. and J. Mann,200320558564Shoeb, M., S.M. MacManus, M. Jaspars, J. Trevidu, L. Nahar, P. Kong-Thoo-Lin and S.D. Sarker,2006Centaurea Montana (Asteraceae) and its in vitro cytotoxic activity against the colon cancer cells.]]>6211721177Yang, C.S. and Z.Y. Wang,19935810381049Galvez, M., C. Martin-Cordero, M. Lopez-Lazaro, F. Cortes and M.J. Ayuso,2003Plantago spp. on cancer cell lines.]]>88125130