Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2012.20.28Andrographis paniculata and Swertia chirayita]]>MenonAditya NagalekshmiR. K. ChandrasekharanDhanya Krishnan NairCherupally Krishnan 1201271Ethanolic extracts of two controversial medicinal plants Andrographis paniculata (ApE) and Swertia chirayita (ScE) were evaluated for its potential to enhance the repair of radiation-induced DNA damage. Post-irradiation administration of these extracts to mice resulted in faster cellular DNA repair, as revealed from the increased Cellular Repair Index (CRI) of blood leukocytes. Exposure of mice to 2 Gy whole-body gamma radiation resulted in the formation of strand breaks of cellular DNA of bone marrow cells and the unrepaired strand breaks eventually lead to the formation of micronuclei in the reticulocytes. Administration of ApE and ScE under post-irradiation conditions showed a decrease in the number of micronucleated reticulocytes. Administration of these extracts also aided in the regeneration of the immune system as revealed from the induction of endogenous spleen colony formation in mice exposed to whole body gamma radiation. Thus, the studies revealed that ethanolic extracts of Andrographis paniculata and Swertia chirayita abetted the revival of immune system following radiation exposure and the induction of faster and legitimate DNA repair can be the underlying mechanism.]]>Chandrasekharan, D.K., T.V. Kagiya and C.K. Nair,2009in vitro, ex vivo, in vivo and oxidative stress in vivo.]]>50203212Gupta, S., M.A. Choudhry, J.N.S. Yadava, V. Srivastava and J.S. Tandon,1990Andrographis paniculata (Kal-Megh) against Escherichia coli enterotoxin in in vivo models.]]>28273283Hayashi, M., T. Morita, Y. Kodama, T. Sofuni and M. Ishidate,1990245245249Hoffmann, G.R., J. Buccola and M.S. Merz,200137117127Joshi, P. and V. Dhawan,2005Swertia chirayita- an overview.]]>89635640Karbownik, M. and R.J. Reiter,2000225922Kehrer, J.P.,1993232148Kitamura, Y., M. Yokoyama, H. Matsuda, T. Ohno and K.J. Mori,1981291159160Konca, K., A. Lankoff, A. Banasik, H. Lisowka and T. Kuszewsk et al.,20035341520Kumar, R.A., K. Sridevi, N.V. Kumar, S. Nanduri and S. Rajagopal,2004Andrographis paniculata.]]>92291295Mathew, D., C.K. Nair, J.A. Jacob, N. Biswas, T. Mukherjee, S. Kapoor and T.V. Kagiya,200748369376Menon, A. and C.K.K. Nair,201184254Mettler, Jr. F.A. and G.L. Voelz,200234615541561Mishra, K., A.P. Dash, B.K. Swain and N. Dey,2009Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin.]]>2009Moulder, J.E.,2002158118124Nagalekshmi, R., A. Menon, D.K. Chandrasekharan and C.K.K. Nair,2011Andrographis paniculata and Swertia chirayita.]]>4933673373Nair, C., D. Parida and T. Nomura,2001422137Nair, R.V.,2004Pages: 257Pages: 257Reen, R.K, M. Karan, K. Singh, V. Karan, R.K. Johri and J. Singh,200175239247Wakeford, R.,20042364046428Schmezer, P., N.R. Behbahani, A.R.S. Thiel, W. Rittgen and P. Drings et al.,2001162530Shukla, S.K and M.L. Gupta,20101118125Singh, N.P.,2000455111127Stone, H.B., J.E. Moulder, C.N. Coleman, K.K. Ang and M.S. Anscher et al.,2004162711728Tan, K.H., D.J. Meyer, N. Gillies and B. Ketterer,1988254841845Till, J.E. and E.A.M. Culloch,196114213222Torous, D.K., N.E. Hall, F.G. Murante, S.E. Gleason, C.R. Tometsko and S.D. Dertinger,200374309314Wiart, C., K. Kumar, M.Y. Yusof, H. Hamimah, Z.M. Fauzi and M. Sulaiman,2005Andrographis paniculata Nees, inhibitors of herpes simplex virus type 1.]]>1910691070