Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2012.1.10Khaya senegalensis]]>NwosuC.U. HassanS.W. AbubakarM.G. EbboA.A 1201271The anti-diarrhoeal, phytochemical and toxicological properties of leaf extracts of Khaya senegalensis were evaluated. Anti-diarrhoeal activities of the extracts were evaluated on castor oil-induced diarrhea in rats and on small intestinal transit. Phytochemical and toxicological studies were carried out using standard methods. The aqueous and methanolic extracts at doses of 100-300 mg kg-1 significantly (p<0.05) reduced the onset of diarrhea and also showed a significant (p<0.05) reduction in gastrointestinal motility on charcoal meal test in rats. The aqueous extract appeared to be more effective than the methanolic extract. Phytochemicals detected in the extracts are saponins, flavonoids, tannins, steroids, alkaloids, glycosides and volatile oils. The LD50 of the aqueous extract was greater than 3000 mg kg-1 per os in rats. Sub-chronic administration of the aqueous extract at 600-3000 mg kg-1 for 28 days resulted in non significant (p>0.05) changes of the renal and liver indices and no histopathological changes of the organs were observed. The results of the study support the traditional use of the plant for diarhoeal remedies and also indicate that the plant has no toxic effect at all the concentrations employed.]]>Abubakar, M., A. Lawal and M. Usman,2009Khaya senegalensis in Albino rats.]]>32628Ammon, H.V., P.J. Thomas and S.F. Phillips,197453374379Anonymous,197916121123Cheesbrough, M.,19912nd Edn.,pp: 508-511, 605pp: 508-511, 605Collins, P.F. and H. Diehl,19593118621867Corless, J. and H. Middleton,198314322912294Di Carlo, G., G. Autore, A.A. Izzo, P. Maiolino and N. Mascolo et al.,19934510541059El-Olemyl, M.M., F.J.A. Muhtadi and A.A. Afifi,1994pp: 1-134pp: 1-134Friedman, L.S. and K.I.J. Isselbacher,199814th Edn.,Gagniella, T.S., J.J. Stewart, W.A. Olsen and P. Bass,1975195335361Galvez, J., A. Zarzuelo, M.E. Crespo, M.D. Lorente, M.A. Ocete and J. Jimenez,1993Euphorbia hirta extract and isolation of an active flavonoid constituent.]]>59333336Gill, L.S.,1992Pages: 276Pages: 276Gornall, A.G., C.J. Bardawill and M.M. David,1949177751766Shoba, F.G. and M. Thomas,2001767376Rao, G.M.M., C.V. Rao, P. Pushpangadan and A. Shirwaikar,2006Rubia cordifolia Linn.]]>103484490Haidet, A.,20032003Harborne, J.B.,19733rd Edn.,pp: 7-13, 60-89, 131-135, 186-188, 203, 279pp: 7-13, 60-89, 131-135, 186-188, 203, 279Harold, V., H.G. Alan and B. Maurice,1980Henry, R.J.,19742nd Edn.,Pages: 525Pages: 525Izzo, A.A., N. Mascolo, R. Capasso, M.P.Germano, R. De pasquale and F. Capasso, 1999360221223Jendrassik, L. and P. Grof,19382297308Jigam, A.A., H.O. Akanya and D.J. Adeyemi,2004Momordica balsamina.]]>81112Kubmarawa, D., M.E. Khan, A.M. Punah and M. Hassan,2008Khaya senegalensis against human pathogenic bacteria.]]>745634566Otshudi, A.L., A. Vercruysse and A. Foriers,200071411423Lott, J.A. and P.L. Wolf,1986pp: 111-138pp: 111-138Macauder, P.J.,1986213489492Malomo, S.O.,2000153338Mascolo, N., A.A. Izzo, G. Autore, F. Berboto and F. Cappasso,1994268291295Morin, L.G. and J. Prox,197360691694Mujumdar, A.M.,1998Azadiachta indica leaf extract.]]>35417420Mukherjee, P.K., K. Saha, T. Murugesa, S.C. Mandal, M. Pal and B.P. Saha,1998608589OECD,200125126Ojo, O.O., M.S. Nadro and I.O. Tella, 20065755760Olayinka, D.O., O. Onoruvwe and T.Y. Lot,1992Khaya senegalensis A. Juss.]]>6282284Park, K., 2000pp: 172-175pp: 172-175Rec GSCC,197210182182Reitman, S. and S. Frankel,1957285663Robert, A., J.E. Nezamis, C. Lancaster, A.J. Hanchar and M.S. Klepper,197611809828Sherlock, S.,1951pp: 204pp: 204Spech, H.J. and H. Liehr,1983218996Trease, G.E. and W.C. Evans,197811th Edn.,Pages: 530Pages: 530Uriyo, A.P. and B.R. Singh,1974pp: 12-14pp: 12-14Viswanathan, S., P.T. Sambantham, J.S. Bapna and L. Kameswaran,1984270151157Wasfi, I.A., A.K. Bashir, M.H. Amiri and A.A. Abdalla,1994Watcho, P., E. Nkouathio, T.B. Nguelefack, S.L. Wansi and A. Kamanyi,2005Oxalis corniculata Klotzsch in rats.]]>14649Wright, P.J. and D.T. Plummer,1974236573Wurochekke, A.U. and A.J. Nok,2004In vitro anti trypanosomal activity of some medicinal plants used in the treatment of trypanosomosis in Northern Nigeria.]]>3481483Wybenga, D.R.D., J. Glorgio and V.J. Pileggi,1971Diacetyl monoxime Method.]]>17891895Zimmerman, M.,198316109110