Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2011.710.714Fumaria parviflora extract on Some Serum Biochemical Parameters of Rats]]>TajikJavad NazifiSaeed PoorzalFahimeh 8201168The effects of long term use of Fumaria parviflora on serum concentrations of total protein, glucose, cholesterol, triglyceride, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and blood urea nitrogen (BUN) were investigated. Three groups of rats (7 rats in each group) were sampled 15 and 30 days after the oral administration of 100, 200 and 300 mg kg-1 of hydroalcoholic extract of the plant and one group (7 rats) was sampled as control. There was no significant difference between treatment and control groups at day 15. At day 30, administration of 300 mg kg-1 of the extract caused a significantly higher serum concentration of AST than other groups (p<0.05). This group also have higher serum ALT than the group which received 100 mg kg-1 of the extract (p = 0.043). The rats that received 300 mg kg-1 of the extract had significantly higher serum total protein than the group which received 100 mg kg-1 of the extract (p = 0.04) and had a marginally higher total protein than the control group (p = 0.08). According to the results of the present study, it seems that long-term administration of F. parviflora extract with lower doses than that reported by other authors may cause hepatic damage.]]>Adewusi,E.A. and A.J. Afolayan,2010413181334Akhtar, M.S., Z. Iqbal, M.N. Khan and M. Lateef,20003899107Nabavizadeh, S.H., O.B. Majid and A. Anushiravani,20093226228Heidari, R.M., A. Mandgary and M. Enayati,2004Fumaria parviflora Lam. in mice and rats.]]>12136140Tripathi, M., B.K. Singh, C. Mishra, S. Raisuddin and P. Kakkar,2010Fumaria parviflora Lam. extract against nimesulide induced apoptosis In vitro.]]>24495508Khalighi, S., D. Yazdani, M. Taghizadeh and Sh.A. Rezazadeh,2005Fumaria parviflora Lam.]]>46262Rao, C.V., A.R. Verma, P.K. Gupta and M. Vijayakumar,2007Fumaria indica whole plant extract in experimental animals.]]>57491498Gilani, A.H., K.H Janbaz and M.S. Akhtar,1996Fumaria parviflora on paracetamol-induced hepatotoxicity.]]>27979983Githiori, J.B., S. Athanasiadou and S.M. Thamsborg,2006139308320Sa, R.C.S., M.N. Leite, V.M. Peters, M.O. Guerra and R.N. Almeida,2006Mikania glomerata hydroalcoholic extract on adult wistar rats In vivo.]]>49599604McGowan, M.W., J.D. Artiss, D.R. Strandbergh and B. Zak,198329538542Burtis, C.A. and E.R. Ashwood,19942nd Edn.,pp: 1002-1093pp: 1002-1093Suau, R., B. Cabezudo, R. Rico, F. Najera and J.M. Lopez-Romero,2002Fumaria species by GC-MS.]]>13363367Wada, Y., H. Kaga, S. Uchiito, E. Kumazawa and M. Tomiki et al.,20077273017306Yu, L.M., X.N. Huang, A.S. Shun, J.S. Shi, Y.F. Lu and K.B. Dai,199913247289Orhan, I.E., B. Sener and S.G. Musharraf,2012Fumaria species and their total phenol and flavonoid quantities.]]>64205209Mehrotra, N.N., S.K. Ojha and S. Tandon,20072007Jelodar, G.H. and S. Nazifi,2000Fumaria parviflora on Biochemical parameter of serum of diabetic rat.]]>515561Karim, A., M.N. Sohail, S. Munir and S. Sattar,20117419439