Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2011.427.432ShethH. SureshD.K. HasanR. KhalidMd S. MaheshS. 4201164The present study was carried out to evaluate the drug-drug interaction between antidiabetic drugs and antihypertensive drug. Interaction of Pioglitazone, the known Thiazolidinedione antidiabetic drug and Nateglinide, the known Meglitinide class antidiabetic drug with Bosentan, an antihypertensive drug was evaluated in healthy and Streptozotocin (STZ) induced diabetic rats. The blood samples were collected from rats at different time interval upto 24 h and blood glucose was estimated. Bosentan (10 mg kg-1, p.o.) pretreatment has not significantly altered the onset of antidiabetic effect of Pioglitazone (0.3 mg kg-1, p.o.) but significantly decreased the peak antidiabetic effect in healthy and Streptozotocin induced diabetic rats (44.74±2.56% reduction before treatment to 34.59±0.25% reduction after treatment), while duration of antidiabetic effect was reduced from 16 h to less than 12 h in both groups. Similarly pretreatment with Bosentan (10 mg kg-1, p.o.) has significantly no effect on the onset of antidiabetic effect of Nateglinide (50 mg kg-1, p.o.) but it significantly reduced the peak antidiabetic effect in healthy and Streptozotocin induced diabetic rats (46.15±1.25% reduction before treatment to 37.57±1.61% reduction after treatment), while duration of antidiabetic effect was reduced from 12 h to less than 8 h in both groups. This study indicates that Therapeutic Drug Monitoring (TDM) has to be required to readjust the therapeutic doses of Bosentan and antidiabetic drugs like Pioglitazone and Nateglinide when they used concomitantly.]]>Sultanpur, C.M., S.V. Kumar and K. Deepa,201111322Sunilkumar, B., P. Lucia and B.D. Miglani,199819193Anitha, N., J.V. Rao, S. Kavimani and V. Himabindu,20083409413Kimberley, M. and Z. Bshouty,200916e54e56Sahi, J, C.B. Black, G.A. Hamilton, X. Zheng and S. Jolley et al.,2003in vitro P450 enzyme induction and inhibition.]]>31439446Kumar, K.S., A. Patel, D. Shirode, P. Baganal, S.V. Rajendra and S.R. Setty,2009439397Parthasarathy, R., R. Ilavarasan and C.M. Karrunakaran,2009Thespesia populnea bark and leaf extract against streptozotocin induced diabetic animals rats.]]>110691072Dingemanse, J. and P.L. van Giersbergen,20044310891115Serasli, E., V. Michaelidis, A. Kosmas, M. Antoniadou and V. Tsara,20105184195Ejuoghanran, O.S.O., O.E. Chukwu and O.E. Fidelis,20099264269