Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2011.158.165HamedManal A 2201162The objective of this study was to mointer the metabolic disturbance in rats one hour after intoxication with one oral dose of ethanol. Rats orally administered with 10 g ethanol/kg body weight on 24 h empty stomach and sacrificed one hour later. Intoxicated rats recorded significant increase in blood alcohol level (alcohol dehydrogenase; ADH), aspartate (AST) and alanine (ALT) aminotransferase, lactate dehydrogenase (LDH) and gamma glutamyl transferase (GGT) enzyme activities. Carbohydrate deficient transferrin (CDT) level as a new marker for detection early independent ethanol intoxication recorded significant increase. Serum transferrin content was evaluated to avoid the false positive results of CDT. In conclusion, AST, ALT, LDH and GGT may be used as biomarkers for early diagnosis of ethanol toxicity. CDT plays a promise role for early diagnosis. CDT and the other biochemical tests especially GGT are recommended to be detected in parallel to improve the performance of either marker used alone.]]>Babson, A.L. and S.R. Babson,197319766769Bautisa, A.P. and J. Spitzer,19994589595Brand, R.M., J.L. Jendrzejewski, E.M. Henery and A.R. Charron,200692349355Chen, J., K.M. Conigrave, P. Macaskill, J.B. Whitfield and L. Irwig,200338574582Fisher, S.J., P.W. Swaan and N.D. Eddington,2010in vitro and oral bioavailability in vivo.]]>332326333Gella, F.J., T. Olivella, P.M. Cruz, J. Arenas, R. Moreno, R. Durban and J.A. Gomez,1985153241247Harasymiw, J. and P. Bean,200136349353Horowitz, M., A. Maddox, M. Bochner, J. Wishart, R. Bratasiuk, P. Collins and D. Shearman,1989257G291G298Krebs, H.A. and J.R. Perkins,1970118635644Lieber, C.S.,200037551584Levitt, M.D. and D.G. Levitt,1994269297304Levitt, M.D., R. Li, E.G. Demaster, M. Elson, J. Furne and D.G. Levitt,1997273G951G957Matsumoto, T., H. Shima, T. Tetsuya Kishi and T. Sato,199145188196Ronald, T., S. Chapman and L. Hall,1983pp: 264-300pp: 264-300Schellenberg, F., R. Schwan, L. Mennetrey, M.N. Loiseaux, J.C. Pages and M. Reynaud,200540531534Sharpe, P.C.,200138652664Sharpe, P.C., R.D. McBride and G.P.R. Archbold,199689137144Stibler, H., S. Borg and M. Joustra,199126451454Szasz, G., 196915124136Vallee, B. and F. Hoch,195577821822Van Pelt, J. and H. Azimi,19984422192220Van Pelt, J., G.L. Leusink, P.W.M. van Nierop and J.J. Keyzer,200024176179Yang, S.S., C.C. Huang, J.R. Chen, C.L. Chiu, M.J. Shieh, S.J. Lin and S.C. Yang,20051172727276Wolff, F., M. Mesquita, F. Corazza, A. Demulder and D. Willems,20104311481151Soliman, K.M., M.A. Hamed and S.A. Ali,20066528536Sillanaukee, P.,199631613616Onyesom, I. and E.O. Anosike,20072337342Koch, H., G. Meerkerk, J.O.M. Zaat, M.F. Ham, R.J. Scholten and W.J. Assendelft,2004397585Karumi, Y., A.I. Augustine and I.A. Umar,2008Adansonia digitata leaf on ethanol-induced ulceration in rats.]]>8225228Golka, K., R. Sondermann, S.E. Reich and A. Wiese,2004151235241Bergstrom, J.P. and A. Helander,2008389164166