Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2011.124.132Kingelia africana (Bignoniaceae)]]>HassanS.W. AbubakarM.G. UmarR.A. YakubuA.S. MaishanuH.M. AyeniG. 2201162Leaf extracts of Kingelia africana were evaluated for wound healing, antibacterial, toxicological and chemical properties. Antibacterial activity was done using hole-in-plate bioassay, wound healing by circular incision, toxicological and chemical properties were evaluated using standard methods. The results show a more rapid wound healing at all the hydromethanolic concentrations employed than 90 mg mL-1 of procaine penicillin on the 4, 7, 10, 13, 16 and 19th day. Exudation was more prominent in control and antibiotic treated groups compared to other groups on day 2 of wounding. Clinical features revealed redness, exudation, scab formation and other changes. The aqueous and organic solvent leaf extracts exhibited significant (p<0.05) antibacterial activity against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli at concentrations ranging from 30 to 120 mg mL-1. Most of the hepatorenal indices were significantly (p<0.05) increased at doses of 2000 to 4000 mg kg-1 indicating compromised functions of these organs. The lethal dose (LD50) of the leaf extract was greater than 3000 mg kg-1. Alkaloids (9.80±0.20), tannins (22.80±0.05), saponins (8.85±0.50), flavonoids (7.80±1.00% w/v), glycosides, saponin glycosides, steroids and anthraquinones were detected. Low values of sodium (6.5±0.01) potassium (3.1±0.01), magnesium (0.126±0.03), phosphorus (2.04±0.04) and calcium (0.108±0.01 mg%) were observed. The results show that leaves extracts of K. africana could be cautiously used and also provide support for the traditional use of the plant in treating bacterial diseases and wound healing due to its chemical constituents.]]>Black, C.A., D.D. Evans, I.E. Evsminger, F.E. Clerk and J.L. White,1965Burkill, H.M.,20002nd Edn.,PP: 293-294PP: 293-294Cheesbrough, M.,1991Vol. II.,pp: 167-214pp: 167-214Clark, R.A.F.,19961996pp: 3-50pp: 3-50Collins, P.F. and H. Diehl,19593118621867Dash, G.K., P. Suresh and S. Ganapaty,2001Lantana camara Linn.]]>1105110Kokane, D.D., R.Y. More, M.B. Kale, M.N. Nehete, P.C. Mehendale and C.H. Gadgoli,2009Mimosa pudica.]]>124311315El-Olemyl, M.M., F.J. Al-Muhtadi and A.A. Afifi,1994pp: 1-134pp: 1-134Essawi, T. and M. Srour,200070343349Gornall, A.G., C.J. Bardawill and M.M. David,1949177751766Grace, O.M., M.E. Light, K.L. Lindsey, D.A. Moholland, J.V. Staden and A.K. Jager,2002Kingelia africana.]]>68220222Kumar, B., M. Vijayakumar, R. Govindarajan and P. Pushpangadan,2007114103113Harborne, J.B.,19733rd Edn.,Hassan, S.W., R.A. Umar, A.S. Yakubu, Y.U. Dabai and A.Y. Abbas,2007Kingelia- africana (Bignoniaceae).]]>22512Hugo, W.B. and A.D. Russel,19833rd Edn.,pp: 167pp: 167Jaffe, M.,198610391400Lott, J.A. and P.L. Wolf,1986pp: 111-138pp: 111-138Mikhalchik, E.V., A.V. Ivanova, M.V. Anurov, S.M. Titkova, L.Y. Penkov, Z.F. Kharaeva and L.G. Korkina,2004137560562Malomo, S.O.,2000153338Morin, L.G. and J. Prox,197360691694Morris, K.S. and K. Aziz,1976Rhamnus frangular L.]]>39223224Muyibi, S.A., B.R. Olorode, P.A. Onyeyili, U.A. Osunkwo, B.Y. Muhammad and O.P. Ajagbonna,2000Cassia occidentalis leaf extract in rats.]]>44851Nayak, S.B. and L.M. Pinto Pereira,2006Catharanthus roseus flower extract has wound healing activity in Sprague Dawley rats. BMC Complement.]]>64146OECD,200125126Okwute, S.K. and A. Mann,1999Commiphora kerstingii Engl. (Burseraceae).]]>26971Owolabi, O.J. and E.K.I. Omogbai,2007Kigelia africana (Bignoniaceae).]]>6582585Owolabi, O.J., F.C. Amaechina and A.B. Eledan,2008Kigelia africana.]]>22023Pattanayak, S.P. and P. Sunita,2008Dendrophthoe falcate (L.f) Ettingsh.]]>120241247Persinos, G.J. and M.W. Quimby,19675615121516Picerno, P., G. Autore, S. Marzocco, M. Meloni, R. Sanogo and R.P. Aquino,2005Kigelia africana and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis.]]>6816101614Rec GSCC,197210182182Reitman, S. and S. Frankel,1957285663Singh, M., R. Govindarajan, V. Nath, A.K.S. Rawat and S. Mehrotra,2006Plagiochasma appendiculatum Lehm. et Lind.]]>1076772Sodipo, O.A., M.A. Akanji, F.B. Kolawole and A.A. Odutuga,1991Garcinia kola, heckle seed.]]>3171171Springfield, E.P. and F. Weitz,2006Carpobrotus mellei L. base on antimicrobial activity and chemical profiling.]]>512891293Starley, I.F., P. Mohammed, G. Schneider and S.W. Bicckler,199925636639Trease, G.E. and W.C. Evans, 197814th Edn.,Uriyo, A.P. and B.R. Singh,1974pp: 12-14pp: 12-14Van Hoof, V.O. and M.E. De Broe,199431197293Varley, H., A.H. Gewenlock and M. Bell,19915th Edn.,pp: 741-742pp: 741-742Vlietinck, J., L. van Hoof, J. Totte, A. Lasure, D.V. Berghe, P.C. Rwangabo and J. Mvukiyumwami,1995463147Wybenga, D.R.D., J. Glorgio and V.J. Pileggi,1971Diacetyl monoxime Method.]]>17891895Zimmerman, M.,198316109110