Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2010.222.228Dillenia indica Linn. Leaves]]>BoseU. GunasekaranK. BalaV. RahmanA.A. 5201055The crude methanol extract of the roots of Dillenia indica Linn. (Family: Dilleniaceae) was investigated for its possible analgesic, antidiarrhoeal and GI motility tests in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg kg-1 b.wt. (p<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg kg-1 of body weight. The crude extract produced significant antidiarrhoeal effect at the dose of 500 mg kg-1 of body weight comparable to that produced by loperamide, used as standard drug. The extract also reduced significantly the charcoal induced Gastro Intestinal (GI) motility in mice; decreased the movement of GI tract in comparison to control animals. This study has found a base stone to step ahead for further researches to make them pharmaceutically useful.]]>Abdille, M.H., R.P. Singh, G.K. Jayaprakasha and B.S. Jena,2005Dillenia indica fruits.]]>90891896Akah, P.A., C.N. Aguwa and R.U. Agu,1999Pentaclethra macrophylla leaf extracts.]]>13292295Awouters, F., C.J.E. Niemegeers, F.M. Lenaerts and P.A.J. Janssen,1978304145Banerji, N., P. Majumder and N.I. Dutta,1975Dillenia indica.]]>14289292Beubler, E. and H. Juan,197931681685Chatterjee, T.K.,19931st Edn.,pp: 133-139pp: 133-139Deraedt, R., S. Jouquey, F. Delevallee and M. Flahaut,1980611724Grover, J.K., S. Yadav and V. Vats,20028181100Haque, M.E., M.N. Islam, M. Hossain, A.U. Mohamad, M.F. Karim and M.A. Rahman,2008Dillenia pentagyna.]]>7103105Keung, W.M. and B.L. Vallee,199847499506Koster, R., M. Anderson and E.J. de Beer,195918412412Kumar, D., S. Mallick, J.R. Vedasiromoni and B.C. Pal,2009Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC.]]>2009Neves, J.M., C. Matos, C. Moutinho, G. Queiroz and L.R. Gomes,2009124270283Parvin, M.N., M.S. Rahman, M.S. Islam and M.A. Rashid,2009Dillenia indica Linn.]]>4122125Peters, O.H.,191010602777Racusen, L.C. and H.J. Binder,197963743749Taesotikul, T., A. Panthong, D. Kanjanapothi, R. Verpoorte and J.J.C. Scheffer,2003Tabernaemontana pandacaqui poir.]]>843135Shoba, F.G. and M. Thomas,2001767376Shome, U., K.R. Khanna and P.H. Sharma,1979Dillenia indica Linn. I. Leaf.]]>883548Shome, U., K.R. Khanna and P.H. Sharma,1980Dillenia indica Linn. II. Fruit and seed.]]>8991104Trease, G.E. and W.C. Evans,19831st Edn.,pp: 307-706pp: 307-706Yeshwante, S.B., A.R. Juvekar, D.M. Nagmoti, S.S. Wankhede, A.S. Shah, R.B. Pimprikar and D.S. Saindane,2009Dillenia indica L. leaves.]]>16366VassarStats, 20092009