Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2009.79.86Acorus calamus Leaves in Mice]]>PandyV. JoseN. SubhashH. 2200942The present study was designed to evaluate CNS depression or analeptic activity of acute oral administration of methanol (ACME) and acetone (ACAE) extracts of Acorus calamus leaves in mice. Spontaneous locomotor activity, immobility time using forced swim test, diazepam-induced sleeping time and motor impairment assessment using rotarod were used to assess CNS depression/analeptic activity of ACME and ACAE in mice. The extracts ACME (5, 20 and 50 mg kg-1, p.o.) and ACAE (20 and 50 mg kg-1, p.o.) significantly decreased the spontaneous locomotor activity in dose dependent manner. The acute treatment of ACME and ACAE (5, 20 and 50 mg kg-1, p.o.) significantly increased the immobility time and decreased the swimming behavior. Administration [6 h prior] of ACME (50 mg kg-1, p.o.) and ACAE (20 and 50 mg kg-1, p.o.) significantly potentiated the diazepam (25 mg kg-1, i.p.)-induced sleeping time in mice. These extracts did not induce disturbance in motor coordination. The results of the present research provided evidences that ACME and ACAE may contain psychoactive substances that are CNS depressant in nature. The CNS depression property of these extracts can be utilized for further anticonvulsant research.]]>Achliya, G.S., S.G. Wadodkar and A.K. Dorle,2005Bramhi ghrita.]]>373336Aqil, F. and I. Ahmad,2007297992Chattopadhyay, D., G. Arunachalam, S.C. Mandal, R. Bhadra and A.B Mandal,20038599105Dandiya, P.C. and H. Cullumbine,1959Acorus calamus (III): Some pharmacological actions of the volatile oil.]]>125353359Dandiya, P.C. and H. Cullumbine,1959Acorus calamus. II. Investigation of volatile oil.]]>11163168Dhalla, N.S. and I.C. Bhattacharya,1968172356365Dunham, N.W. and T.S. Miya,195746208209Gilani, A.U., A.J. Shah, M. Ahmad and F. Shaheen,2006Acorus calamus Linn. is mediated through calcium channel blockade.]]>2010801084Hazra, R. and D. Guha,2002Acorus calamus on electrical activity and regional monoamine levels in rat brain.]]>17161169Hazra, R., K. Ray and D. Guha,2007Acorus calamus in ferric chloride-induced epileptogenesis in rat.]]>26947953Kulkarni, S.K. and A.K. Metha,198585460463LeMoal, M. and H. Simson,199171155234Malhotra, C.L., P.K. Das and N.S. Dhalla,1962138537547Motley, T.J.,1994Acorus calamus (Araceae).]]>48397412Mukherjee, P.K., K. Venkatesan, M. Mainak and H. Peter,200745651666Pal, D. and M. Nandi,200562355361Panchal, G.M., H. Venkatakrishna-Bhatt, R.B. Doctor and S. Vajpayee,1989Acorus calamus L.]]>27561567Porsolt, R.D., A. Bertin and M. Jalfre,197851291294Porsolt, R.D., A. Bertin and M. Jalfre,1977229327336Salamone, J.D., M. Correa, S.M. Mingote and S.M. Weber,200553441Seto, T.A. and W. Keup,1969180232240Tremblay, L.K., C.A. Naranjo, L. Cardenas, N. Herrmann and U.E. Busto,200259409416Vohora, S.B., S.A. Shah and P.C. Dandiya,1990Acorus calamus rhizomes.]]>285362Evans, W.C., 200215th Edn.,Kim, H., T.H. Han and S.G. Lee,2009Acorus calamus L. leaves on keratinocyte HaCaT cells.]]>122149156Nadkarni, K.M.,20073rd Edn., Vol. I,pp: 35-37pp: 35-37Prajapati, N.D., S.S. Purohit, D.D. Sharma and K. Tarun,20031st Edn.,pp: 13-14pp: 13-14Tkachev, A.V., A.M. Gurev and M.S. Yusubov,200642696698