Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2009.300.306Lagenaria siceraria: An Experimental Study using
Acute Stress Models on Rats]]>LakshmiB.V.S. SudhakarM. 8200948This study was conducted to evaluate the anti-stress potential of ethanolic extract of fruits of Lagenaria siceraria in rats. The present study was to investigate the influence of forced swimming endurance stress on swimming endurance time, organ weights and changes in biochemical parameters in rats. The purpose of the study was also to investigate the acute heat stress induced changes in biochemical parameters, adrenal gland weight and stress induced perturbations in blood cell counts in albino Wistar rats. These activities were tested at oral doses of 100-400 mg kg-1 of the extract using Withania somnifera as a standard reference drug. Pretreatment with the extract at different doses significantly (p<0.05) ameliorated the stress-induced variations in this biochemical parameters-serum glucose, triglyceride, cholesterol, BUN and cortisol levels, blood cell counts and organ weights in these stress models. The extract treated animals also showed increase in swimming endurance time. This ability of Lagenaria siceraria to prolong the swimming time and ameliorate the stress induced changes in both stress models, therefore, suggests an antistress and adaptogenic property.]]>Abel, E.L.,199149321323Anisman, H. and Z. Merali,199923241249Amarnath, B., S.M.S. Kumar and N.V. Rao,2006Sida cordifolia, Linn.]]>432530Archana, R. and A. Namasivayam,1999Withania somnifera.]]>649193Krauze-Baranowska, M. and W. Cisowski,1994675240243Brown, G.W.,199355248259Dominiczak, B.,1999pp: 257-258pp: 257-258Ghule, B.V., M.H. Ghante, A.N. Saoji and P.G. Yeole,2006Lagenaria siceraria (Mol.) fruit extracts.]]>44905909Ghule, B.V., M.H. Ghante, P.G. Yeole and A.N. Saoji,2007Lagenaria siceraria fruit extracts in rats.]]>69817819Greenen, D., P. Buttrick and J. Scheuer,198865116123Fard, M.H., S.L. Bodhankar and M. Dikshit,2008Lagenaria siceraria (Molina) standley on doxorubicin induced cardiotoxicity in rats.]]>4466471Jiwjinda, S., V. Santisopasn, A. Murakam, O.K. Kim, H.W. Kim and H. Ohigashi,20023215223Kannur, D.M., V.I. Hukkeri and K.S. Akki,2006Caesalpinia bonduc seed extracts in rats.]]>108327331Kiritikar, K.R. and B.D. Basu,20012nd Edn.,Kramer, K., H. Dijkstra and A. Bast,199353271276Krupavaram, B., N. Venakat Rao, K. Nandakumar, T.S. Gowda, M.D. Shalam and S. Shantakumar,2007Boerhaavia diffusa (Linn).]]>44264270Nadkarani, K.M.,19823rd Edn., Vol. 2,Pages: 133Pages: 133Nagaraja, H.S. and P.S. Jeganathan,1999435359Panossian, A., G. Wikman and H. Wagner,19996287300Porsolt, R.D., M. le Pichon and M. Jalfre,1977266730732Rai, D., G. Bhatia, G. Patil, R. Pal, S. Singh and H.K. Singh,2003Bacopa monniera (Bramhi).]]>75823830Richter, C.P.,195719191198Shirwaikar, A. and K.K. Sreenivasan,1996Lagenaria siceraria.]]>58197202Sen, P., P.C. Maiti, S. Puri, A. Ray, N.A. Audulov and A.V. Valdman,1992Ocimum sanctum (Linn), eugenol and Tinospora malabarica in experimental animals.]]>30592596Sadock, B.J. and V.A. Sadock,20039th Edn.,pp: 534-590pp: 534-590Schimmer, B.P. and K.L. Parker,200611th Edn.,pp: 1655-1662pp: 1655-1662Tan, N., K. Morimoto, T. Sugiura, A. Morimoto and N. Murakami,199251927931Thiebot, M.H., P. Martin and A.J. Puech,1992154450Tache, Y. and H. Selye,197622325336Vogel, W.H.,199312265271Wang, H.X. and T.B. Ng,2000Lagenaria siceraria) seed.]]>6726312638