Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2009.107.116of Mus musculus Mice]]>SoniArvind ChaudharyManu DwivediVivek Kumar 3200943The aim of the present study was to evaluated the effect of the VRP 1020 in reconstitution with fixed dose combination of ceftriaxone-vancomycin (Vancoplus). The mice were fed standard pelleted diet and water ad libitum. The test room was air conditioned with temperature 23±20°C, humidity 65±5% and with artificial fluorescent light (10-14 h) of light and dark, respectively. Thirty Mus musculus mice (weighing 30±5 g) were divided into 5 groups containing 6 mice in each group. Group I: control (normal saline), group II: ceftriaxone (28.57 mg kg-1 body weight/day) group III: vancomycin (14.2 mg kg-1 body weight/day), group IV: ceftriaxone-vancomycin (42.8 mg kg-1 body weight/day) and group V: ceftriaxone-vancomycin+VRP 1020 (42.8 mg kg-1 body weight/day). Present finding showed that activities of antioxidant enzymes (superoxide dismutase and catalase) and pyridoxal-5-phosphate level (biologically most active co-enzyme of vitamin B6) were significantly increased along with decreased in lipid peroxidation (malonaldialdehyde) level in vancoplus treated group as compared to ceftriaxone and vancomycin alone and combination of ceftriaxone-vancomycin treated group. Similarly, the levels of extracellular antioxidant (creatinine and uric acid) were found to be significant lowered in vancoplus treated group when compared to ceftriaxone, vancomycin and ceftriaxone-vancomycin treated group. These results indicated that reconstitution of VRP 1020 with fixed dose combination of ceftriaxone-vancomycin protects against ceftriaxone and vancomycin induced nephrotoxicity that improved the activities of free radical scavenging enzymes.]]>Abrutyn, E., L. Lincoln, M. Gallagher, J. Allan and M.D. Weinstein,19784153158Anghehrn, P.,1983In vitro and In vivo synergy between ceftriaxone and aminoglycosides against Pseudomonas aeruginosa.]]>2489495Appel, G.B., D.B. Given, L.R. Levine and G.L. Cooper,198687580Beam, T.R.A.,19855237253Cam, M.S., O. Seref, S.E. Tunc, C. Arslan, E. Uz and H.R. Yilmaz,20062915561Chakraborty, S., P.D. Bhuti, S. Ray, C. Sengupta and K. Roy,200560141143Chaudhary, M., S.M. Shrivastava and R. Sehgal,200838285Chaudhary, M., A. Soni, V. Dwivedi and S.M. Shrivastava,2008Mus musculus mice.]]>3211214Chaudhary, M. and S.M. Shrivastava,2005Staphyloccous aureus.]]>17382384Creekmore, F.,199851195196Dellinger, P., T. Murphy, V. Pinn, M. Barza and L. Weinstein,19796172178Duffull, S.B. and E.J. Begg,199413103114Dwivedi, V.K., M. Chaudhary, A. Soni and S.M. Shrivastava,2009Mus musculus mice.]]>41321Fanos, V. and L. Cataldi,199920245267Farber, B.F. and R.C. Moellering,198323138141Fekety, F.R.,19908838S44SFrancioli, P.B., M. Glauser,1993Streptococcal endocarditis.]]>37207212Friedland, I.R., M. Paris, S. Ehrett, S. Hickey, K. Olsen and G.H. McCracken,1993pneumococcal meningitis.]]>3716301636Klugman, K.P., I.R. Friedland and J.S. Bradley,1995Streptococcus pneumoniae in cerebrospinal fluid of children with acute bacterial meningitis.]]>3919881992Kojima, R., M. Ito and Y. Suzuki,198951465473Luck, H.,19651965pp: 885-894pp: 885-894Luft, F.C., V. Patel, M.N. Yum amd S.A. Kleit,19759831833Luming, L., R.E. Brashear and K.L. Ting,197484339348Matzke, G.R., G.G. Zhanel and D.R.P. Guay,198611257282Misra, H.P. and I. Fridovich,197224731703175Nahata, M.C. and W.J. Barson,198519900906Ohkawa, H., N. Ohishi and K. Yagi,197995351358Oktema, F., M.K. Arslana, F. Ozgunerb, O.H. Candirc, R. Yilmazd, M. Cirisc and E. Uzd,2005In vivo evidences suggesting the role of oxidative stress in pathogenesis of vancomycin-induced nephrotoxicity: Protection by erdosteine.]]>215227233Richards, D.M., R.C. Heel, R.N. Brogden, T.M. Speight and S. Avery,198427469527Roy, K., A. Saha, K. De and C. Sengupta,200057385390Rybak, M.J., L.M. Albrecht, S.C. Boike and P.H. Chandrasekar,199025679687Tripta, C., M. Shrivastava and S.M. Varughese,2007Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa.]]>192125Yasin, K.F., M. Sabir, M.I.K. Sherwani, M. Zafar, S. Yasmin and M.I. Alam,2003426973Yasin, K.F., M. Sabir, S. Yasmin and M. Khan,200241148151