Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2008.84.92in vitro Tool for Predicting Dose Dumping from Controlled Release Matrices]]>EmejeM.O. NwabunikeP.I. IsimiC.Y. KunleO.O. OfoefuleS.I. 2200832In present study, the release profiles of hydrochlorothiazide from polyacrylic acid polymer (carbopol 71G) matrices in hydro-ethanolic media were done. Percent drug released increased with increasing levels of ethanol in the dissolution media, but there was no direct correlation with the drug`s solubility in the media. Although, the result showed that an initial rapid release was observed in the media containing 30% ethanol, this could not be regarded as dose dumping of hydrochlorothiazide. Release in this medium was considered to be both erosion and diffusion-mediated, in contrast to the release in 0, 10, 20, 40 and 50% ethanol media, where erosion-controlled release dominated. Image analysis of matrix swelling and swelling kinetics suggests a complex interaction between ethanol, hydrochlorothiazide and Carbopol 71 G accounting for the suppressed drug release in the ethanolic-media.]]>Aditya, S.T., K.A. Mehta, L.L. Augsburger and S.W. Hoag,200493923192331Anonymous,20062006Conti, S., L. Maggi, L. Segale, E. OchoaMachiste, U. Conte, P. Grenier and G. Vergnault,2007333136142Emeje, M.O. and O.O. Kunle,2004ficus sur.]]>3-4147154Emeje, M.O., O.O. Kunle and S.I. Ofoefule,200535661Emeje, M.O., O.O. Kunle and S.I. Ofoefule, 200656325335Emeje, M.O., O.O. Kunle and S.I. Ofoefule,20067E18E21Ford, J.L., K. Mitchell, P. Rowe, D.J. Armstrong, P.N.C. Elliott, C. Rostron and J.E. Hogan,19917195104Ganesh, S., B. Bommareddya, A.S. Paker-Leggs, K.K. Saripella and S.H. Neaua,20063216271Grabovac, V., D. Guggi and A. Bernkop-Schnurch,20055717131723Juarez, H., G. Rico and L. Villafuerte,2001216115125Mitchell, K., J.L. Ford, D.J. Armstrong, P.N.C. Elliott, C. Rostron and J.E. Hogan,199066233242Roberts, M., M. Cespi, J.L. Ford, A.M. Dyas, J. Downing, L.G. Martini and P.J. Crowley,20073323137Sujja-Areevath, J., D.L. Munday, P.J. Cox and K.A. Khan,19961395362Vargas, C.I. and E.S. Ghaly,19992510451050Varshosaz, J., N. Tavakoli and F. Kheirolahi,20067E168E174Vazquez, M.J., B. Perez-Marcos, J.L. Gomez-Amoza, R. Martinez-Pacheco, C. Souto and A. Concheiro,19922025192526