Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2008.409.413AnithaN. RaoJ.V. KavimaniS. HimabinduV. 5200835The present study is aimed to explore the pharmacodynamic
interaction of metformin with statins like atorvastatin and rosuvastatin
in rats. Wistar albino rats of either sex (150-200 g) were induced diabetes
by administering alloxan and they were divided into six groups, each consisting
of six rats. Normal control group (1) is treated with 1%w/v carboxy methyl
cellulose (CMC) suspension. Group 2 served as diabetic control. To the
diabetic 3rd, 4th and 5th group metformin, atorvastatin and rosuvastatin
were administered orally respectively for 7 days. The combination of metformin
+ atorvastatin and metformin + rosuvastatin were administered to the 6th
and 7th group of diabetic rats for 7 days. On the last day blood samples
were collected, serum was isolated and subjected to glucose, triglycerides
(TG), total cholesterol (TC), low density lipoprotein (LDL) and high density
lipoprotein (HDL) estimation. Body weight was also calculated. Metformin
significantly reduced the serum glucose level in diabetic rats. Atorvastatin
and rosuvastatin produced mild hypoglycemia. On the other hand the combination
of metformin + atorvastatin and metformin + rosuvastatin significantly
reduced the serum glucose level when compared to metformin alone. Atorvastatin
and rosuvastatin significantly reduced the serum TG, TC and LDL and increased
HDL level. Metformin also altered the lipid profile of diabetic rats.
Whereas the combination of metformin + atorvastatin and metformin + rosuvastatin
significantly reduced the lipid profile when compared to atorvastatin
and rosuvastatin alone. The combination of drugs also increased the body
weight of diabetic animals. The antidiabetic drug metformin enhanced the
hypolipidemic activity of atorvastatin and rosuvastatin. Similarly atorvastatin
and rosuvastatin enhanced the hypoglycemic activity of metformin due to
pharmacodynamic interactions.]]>Alan, S.N. and P.S. Stephen,19961996pp: 51.pp: 51.Allain, C.C., L.S. Poon, C.S.G. Chan, W. Richmond and P.C. Fu,197420470475Babu, V., T. Gangadevi and A. Subramanium,2002Cassia kleinii leaf extract in glucose feed normal rats and alloxan-induced diabetic rats.]]>34409415Babu, V., T. Gangadevi and A. Subramanium,2003Cassia kleinii leaf in streptozotocin induced diabetic rats and isolation of an active fraction and toxicity evaluation of the extract.]]>35290296Cerveny, J.D., R.D. Leder and C.W. Weart,199832896905Chakrabarti, R and R. Rajagopalan,20028315331538Dhanabal, S.P., C.K. Kokate, M. Ramanathan, K. Elango and E.P. Kumar et al.,2004Polygala arvensis in alloxan diabetic rats.]]>41690695Dhawan, D., H.K. Bandhu, B. Singh, A. Singh and J.P. Nagpal,199628224226Fossati, P. and L. Prencipe,19822820772080Khan, C.R. and Y. Schechter,19911991pp: 1463-1495pp: 1463-1495Khosla, P., D.D. Gupta and R.E. Nagpal,1995Trigonella foenum graecum (Fenugreek) on serum lipids in normal and diabetic rats.]]>278993Lopes-Virella, M.F., P. Stone, S. Ellis and J.A. Colwell,197723882884Nikkhila, E.A. and M. Kekki,197322122Satyanarayana, S., M. Nitin and K. Prasad,200744683688Trinder, P.,196962427Trivedi, N.A., B. Mazumdar, J.D. Bhatt and K.G. Hemavathi,200436373376Yuan, R., T. Parmelee, J.D. Balian, R.S. Uppoor and F. Ajayi et al.,1999In vitro metabolic interaction studies: Experience of the food and drug administration.]]>66915