Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2008.373.377AzibaPeter I. 5200835Prototype agents such as Acetylcholine (1.0x10-9
to 5.0x10-9 M), Nor-adrenalin (2.5x10-8 to 4.2x10-7
M) and Potassium (50 mM) which stimulate different receptor populations
in smooth muscle contraction have been examined on the contractility in
Rat Vas Deferens (RVD) and Rat Stomach Strip (RSS) in various Physiological
Salt Solution (PSS), varying the extra- cellular calcium in the medium
shows a reversed sigmoidal curve in both tissues. In Ca2+-free
medium, the rat vas deferens contractility diminished rapidly <10 min,
but the rat stomach strip, maintained successively diminished and remained
stable after 1 h of this treatment. The contractile heights diminished
as extracellular Ca2+ decreases in the bathing PSS from 1.8
mM Ca2+ to 0.9 mM Ca2+ and 0.45 mM Ca2+
and Ca2+-free medium, (64, 81 and 98.2% in RVD and 31, 68 and
87% in RSS. In Depolarising medium, both tissues looses contractility
rapidly less than five minutes in RVS and RSS maintained diminished contractions
for over 1 h. The results in this study suggest that the rat stomach strip
under the experimental conditions has more intra cellular calcium storage
when compared to contractility in rat vas deferens.]]>Aziba, P.I. and M.C. Okunola,199922327Chiu, A.T., D.E. McCall and P.B. Mimmermans,1986+ channel in Rat aorta.]]>12718Gillespie, J.S.,197245404416Hurwitz and A. Suria,197111303326Karaki, H.H., O.M. Hori, M. Mitsui and K.I. Saito,199749157230Koch, P., B. Wilfert, D. Withelm and T. Peters,1990342454461Minnermann, K.P.,19884087119Nishimura, M.,199132555561Putney, J.N.,1990271365372Vane, J.R.,195712344349