Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2008.246.253HalderG. SamantaG. MondalS. RoyB. DharaK.C. KoleyS. 4200834An experiment was conducted to find out the effect of excess methionine and methionine-betaine supplementation on deposition of arsenic in different tissues, organs and eggs of hen and contribution of hen egg and meat to human health hazard along with the arsenic contaminated drinking water. One hundred twenty Rhode Island Red, 16 week-old, were allocated into four groups having three replicates with nine hens and one cock in each replicate. The experimental groups were C (control group fed with basal diet only), T1 (fed control diet with 5.5 ppm arsenic through water), T2 (fed control diet with 5.5 ppm arsenic through water + 50 g methionine per 100 kg of feed) and T3 (fed same as T2 but 50% of the excess methionine supplement was replaced with betaine). The birds were maintained in deep litter system of housing. Statistical analysis confirmed that the concentration of arsenic in different organs, tissues and eggs were varied significantly (p< 0.01) due to dietary treatments. The long term intake of such arsenic contaminated hen eggs and meat by human being may act as some contributory factor to suffer from the serious health hazard. Statistical analysis confirmed that the concentration of arsenic (As) in various organs, tissues and eggs was significantly (p< 0.01) reduced due to supplementation of methionine and methionine-betaine in T2 and T3 groups, respectively as significantly (p< 0.01) larger amount of arsenic was voided through faeces in T2 and T3 groups than T1 group where no excess methionine or betaine was added in diet. So it may be concluded that supplementation of either methionine or methionine-betaine combination may able to protect the chronic arsenic toxicity during exposure of As in laying hen.]]>Anke, M., G. Hoffman, M. Grun, B. Groppel and E. Riedel,1982267135146AOAC.,198013th Edn.,pp: 56-132pp: 56-132AOAC.,199516th Edn.,Balatskii, K.P.,198996163BIS,19921992Buchet, J.P. and R. Lauwerys,1985in vitro: Relevance for the interpretation of observation in man.]]>57125129Chiou, W.J., K. Chen, B. Yu, W.S.P. Chiou, K.L. Chen and B. Yu,199774229236Chowdhury, U.K., M.M. Rahman, B.K. Mandal, K. Paul and D. Lodh et al.,20018393415Duncan, D.B.,195511142Hoffman, D.J., C.J. Sanderson, L.J. Le Captain, E. Cromartie and G.W. Pendleton,1992225562Holeman, A. and V. Stibilij,199732407410Hopenhayn-Rich, C., M.L. Biggs, D.A. Kalman, L.E. Moore and A.H. Smith,199610412001207Hulinger, G., L. Sangster, B. Colvin and K. Frazier,199840147148Lindgren, A., M. Vahter and L. Dencker,198274As-arsenite or arsenate.]]>51253265MFPO,19921992Proudfoot, F.G., E.D. Jackson, H.W. Hulan and C.D.C. Salisbury,199171221226Smith, A.H., M.L. Biggs, L. Moore, R. Haque, C. Steinmaus, J. Chung, A. Hernandez and P. Lopipero,19991999pp: 191200SPSS,1997Szinicz, L. and W. Forth,19882O3 on gluconeogenesis.]]>61444449Vahter, M. and E. Marafante,1983472944Vaheter, M. and E. Marafante,1987374146Vasak, V. and V. Sedivec,195246341344WHO,1981WHO,19961996Yamauchi, H. and Y. Yamamura,198534113121