Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2007.737.742Tylophora asthmatica Against Paracetamol-Induced Liver Damage in Rats]]>MalathiR. GomezM. Patrick 8200728The aim of the present study was to evaluate the hepatoprotective and antioxidant properties of methanolic leaves extracts of Tylophora asthmatica (META) on paracetamol-induced (1 g kg-1 body weight, i.p.,) hepatotoxicity in wistar strain of rats. The extract produced significant hepatoprotective effects as evidenced by decreased (p< 0.05) serum enzyme activities, ALT, AST, ALP, LDH and serum bilirubin (200 mg kg-1 body weight orally for 21 days) compared with control group. For antioxidant activity, META exhibited significant (p< 0.05) hepatoprotective effect by increasing the levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and reducing lipid peroxidation (LPO). These results suggest that META may have hepatoprotective potential, probably by its antioxidant properties on hepatocytes and also support the use of the plant as a hepatoprotective agent.]]>Akintonwa, A. and A.R. Essien,1990Garcinia kola seed extracts against paracetamol-induced hepatotoxicity in rats.]]>29207211Bokov, A., A. Chaudhuri and A. Richardson,2004125811826Boyd, E.H. and G.M. Bereczky,196626606614Boyer, T.D. and S.L. Rouff,1971218440441Chaterrjee, T.K.,2000pp: 143pp: 143Coles, B., I. Wilson, P. Wardman, J.A. Hinson, S.D. Nelson and B. Ketterer,1988264253260Dahlin, D.C., G.T. Miwa, A.Y.H. Lu and S.D. Nelson,19848113271331Dai, Y. and A.I. Cederbaum,199527314971505Drotman, R.B. and G.T. Lawhorn,19781163171Giordano, F.J., 2005115500508Gopalakrishnan, C., D. Shankaranarayan, L. Kameswaran and S. Natarajan,1979Tylophora asthmatica.]]>69513520Gopalakrishnan, C., D. Shankaranarayan, S.K. Nazimudeen and L. Kameswaran,1980Tylophora indica, on immunopathological and inflammatory reactions.]]>71940948Jaeschke, H.,200015718724Jaeschke, H., T.R. Knight and M.L. Bajt,2003144279288James, L.P., P.R. Mayeux and J.A. Hinson,20033114991506Karan, M., K. Vasisht and S.S. Handa,1999Swertia chirata on carbon tetrachloride-induced hepatotoxicity in rats.]]>132430King, J.,19651965pp: 363-395pp: 363-395King, J.,19651965pp: 83–93pp: 83–93King, J.,19651965pp: 191-197pp: 191-197Klaunig, J.E. and L.M. Kamendulis,200444239267Lin, C.C., L.T. Ng, J.J. Yang and Y.F. Hsu,200230225234Lowry, O.H., N.J. Rosenbrough, A.L. Farr and R. Randall,1951193265275Malloy, H.T. and K.A. Evelyn, 1937119481490Moron, M.S., J.W. Depierre and B. Mannervik,19795826778Misra, H.P. and I. Fridovich,197224731703175Moldeus, P.,19782728592863Nakamura, W., S. Hosoda and K. Hayashi,1974358251261Ohkawa, H., N. Ohishi and K. Yagi,197995351358Plaa, G.L. and W.R. Hewitt,1982Yoshida, H., Y. Hagihara and S. Ebashi (Eds.). Vol. 5.pp: 65-75pp: 65-75Rolo, A.P. and C.M. Palmeira,2006212167178Savides, M.C. and F.W. Oehme,1983396111Sherlock, S. and J. Dooley,20022002pp: 335-365pp: 335-365Shivpuri, D.N., S.C. Singhal and D. Parkash,1972Tylophora indica: A cross-over, double-blind study.]]>30407412Sinha, A.K.,197247389394Thomsen, M.S., S. Loft, D.W. Roberts and H.E. Poulsen,199576395399Udupa, A.L., S.L. Udupa and M.N. Guruswamy,1991Tylophora asthmatica on pituitary-adrenal axis in albino rats.]]>57409413Verma, G.S., V. Ramakrishnan, N.B. Mulchandani and M. Chadha,19861986Vermeulen, N.P.E., J.G.N. Bessems and R. Van de Straat,199224367407Rotruck, J.T., A.L. Pope, H.E. Ganther, A.B. Swanson, D.G. Hafeman and W.G. Hoekstra,1973179588590