Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2007.278.283Mammea africana(Guttiferae) in Streptozotocin Induced Diabetic Rats]]>OkokonJude E. AntiaBassey S. OsujiL.C. UdiaPius M. 3200723Evaluation of antidiabetic and hypolipidaemic activities of ethanolic stembark extract of Mammea africana in rats was carried out. Treatment of streptozotocin diabetic rats with the extract caused a significant (p< 0.01) reduction in fasting Blood Glucose Levels (BGL) of the diabetic rats both in acute study and prolonged treatment (2 weeks). The activity of the extract was comparable to that of the reference drug, glibenclamide. M. africana treatment showed considerable lowering of serum total cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and an increase in HDL cholesterol in the treated diabetic group. This results suggest that the stembark extract of M. africana possesses antidiabetic and hypolipidaemic effect on streptozotocin induced diabetic rats.]]>Amic, D., D. Davidovic-Amic, D. Beslo and N. Trinajstic,2003765561Balkau, B., M.A. Charles and E. Eschwege,20002229234Carpenter, I., E.J. McGarry and F. Scheiman,1970Mammea africana G.]]>4639833986Carpenter, I., E.J. McGarry and F. Scheimann,1971Mammea africana G.]]>2237833789Chapius, J.C., B. Sordat and K. Hostettman,19882322273284Crichton, E.G. and P.G. Waterman,1978Mammea africana.]]>1717831786Dalziel, J.M.,19561956Djrolo, F., H. Houngbe, G. Avode, G.B. Addra, N. Kodjoh, M. Avinadje and B. Monterio,1998Diabete tropical).]]>45538542Friedewald, W.T., R.I. Levy and D.S. Fredrickson,197218499502Gartlans, J.S., M.C.P.G. Key, D.B. Waterman, C.N. Mbi and T.T. Struhsaker,19808401422Grodsky, G.M., G.H. Epstein, R. Fanska and J.H. Karam,19713627192728Igarasi, K. and M. Ohmuma,199559595601Ivorra, M.D., M. Paya and A. Villar,198927243275Kamtchouing, P., S.D. Sokeng, P.F. Moundipa, P. Watcho, H.B. Jatsa and D. Lontsi,1998Anacardium occidentale extract against streptozotocin-induced diabetes in rats.]]>629599Kaplan, N.M.,198914915141520Krishnakumar, K., K.T. Augusti and P.L. Vijayammal,2000Salacia oblonga Wall. root bark in streptozotocin diabetic rats.]]>286567Kumar, G.P.S., P. Arulselvan, D.S. Kumar and S.P. Subramanian,2006Terminalia chebula on streptozotocin induced diabetic rats.]]>52283291Mironova, M.A., R.L. Klein, G.T. Virella and M.F. Lopes-Virella,2000in vitro oxidation in patients with type-2 diabetes.]]>4910331041Nabel, E.G.,20033496072Nagappa, A.N., P.A. Thakurdesai, N. Venkat Rao and J. Singh,2003T. catappa Linn.]]>91109113Okokon, J.E., A.E. Udokpoh, G.A. Essiet,200634349Ouahouo, B.M., A.G. Azebaze, M. Meyer, Z.T. Bodo B. Fomum and A. Nkengfack,2004Mammea africana.]]>98733739Pari, L. and M.A. Satheesh,2004Boerhaavia diffusa L.: Effect on hepatic key enzymes in experimental diabetes.]]>91109113Atta-ur-Rahman and M. Choudhary,200173555560Reher, G., M. Slijepcevic and L. Krans,1991Sarcopoterium spinosum and two Sanguisorba sp.]]>57A57A58Shimizu, M., T. Ito, S. Terashima, Hayashi, T. and M. Arisawa et al.,19842318851888Szkudelski, T.,200150537546Tomoda, M., K. Shimada, C. Konno and H. Hikino,1985Panax ginseng roots.]]>2424312433WHO,19801980Yanardag, P. and H. Colak,1998Beta vulgaris L. Varcida) on blood glucose levels in Normal and alloxan induced diabetic rabbits.]]>4309311Zimmet, P.,2000247301310