Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2006.383.388GadirWarda S. AbdelEdeenMohy AlazaimD. Abu BakhietAmel O. FadlallaI.M.T. 4200614This study was done on 40 Bovans-type chicks to investigate the possible toxic effects of the therapeutic doses of the antimalarial drugs, Quinine and Fansidar and their combined doses. After two weeks (adaptation period), the drugs were dissolved in distilled water in concentrations of 4.33 mg mL day-1 for Quinine, 4.19 mg mL day-1 for Fansidar and their mixture (4.33 mg Quinine plus 4.19 mg Fansidar) mL day-1 and given orally to Bovans chicks for two weeks. The effects on growth and tissues were investigated. After one week, there was no change in growth and at post-mortem examination, there was congestion of liver in all tested chicks and haemorrhage on the heart of chicks that had been given Fansidar. Serobiochemical changes were increase in the activities of AST, ALT and in concentration of albumin, uric acid, total protein and globulin and decrease in cholesterol levels. There were decreases in haemoglobin, PCV, MCV and MCH values. At the end of two weeks, there was depression in growth of tested chicks, degeneration of the liver of chicks that had been given Quinine and mixture of Quinine plus Fansidar and cardiac haemorrhage in chicks that had been given fansidar and or quinine plus fansidar with increases in AST, ALT activities and in total protein concentration with decreases in globulin levels and PCV values.]]>Bateman, D.N., P.G. Blain and K.W. Woodhouse,198554125131Bateman, D.N. and E.H. Dyson,19865215233Chazquileres, O. and A. Robert,1996Dannenberg, A.L., S.F. Dorfman and J. Johnson,198376846849Dyson, E.H., A.T. Proudfoot, L.F. Prescott and R. Heyworth,19852913133Farver, D.K. and M.N. Lavin,1999333234Glynne, P., A. Sama, A. Cheudhry, D. Swirsky and L. Lightstone,199933133137Horgan, S.E. and R.W. Williams,19959637638Joseph, R.D.,19901990pp: 646-657pp: 646-657Kimber, C., R.S. Oliver and A.H. Aster,196538767767Laurence, D.R., P.N. Bennett and M.J. Brown,19978th Edn.,pp: 255-299pp: 255-299Licciardello, A.T. and J.B. Stanbury,1984238120121Marr, J.J.,19851985McEvoy, G.K.,1994pp: 464-367pp: 464-367Philip, J.R. and S.G. Robert,20012001pp: 887-891pp: 887-891Reynolds, J.E.F.,199631st Edn.,Rollo, I.M.,19751975pp: 1062-1065pp: 1062-1065Schalm, O.W., N.C. Jain and G.H. Carroll,19753rd Edn.,Pages: 807Pages: 807Simons, C.T., M. Mahony and E. Carstens,200227353365Snedecor, G.W. and W.C. Cochran,19898th Edn.,Wolf, L.R., E.J. Otten and M.P. Spadafora,199210295301