Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2006.278.283in vitro Antibacterial Activity of Methanol and Ethanol Extracts of Carica papaya Flowers and Mangifera indica Leaves]]>ZakariaZ.A. JaisA.M. Mat SulaimanM.R. Mohamed IsaS.S.P. RiffinS. 3200613The present study was carried out to evaluate the possible antibacterial activity of methanol and ethanol extracts of Mangifera indica leaves and Carica papaya flowers using the in vitro disc diffusion methods. The sterilized blank discs (6 mm diameter) was impregnated with 20 μL of the respective extract in the concentrations of 12.5, 25, 50 and 100% and tested against Corneybacterium diptheriae, Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhi, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris. The methanol and ethanol extracts of M. indica were effective against C. diptheriae, S. aureus, S. typhi and P. aeruginosa, with the latter producing slightly bigger inhibitory zone against some of the bacteria when compared to the former. The methanol and ethanol extracts of C. papaya were effective only against S. aureus and S. pneumoniae, with the latter also effective against C. diptheriae.As a conclusion, the present study demonstrated the potential of M. indica leaves and C. papaya flowers as antibacterial agents against some of the bacteria tested and thus may provide the basis for the isolation of bioactive compounds with antibacterial activity from the respective plant leaves or flowers.]]>Aderibigbe, A.O., T.S. Emudianughe and B.A. Lawal, 2001Mangifera indica in mice. ]]>15456458Bennett, R.N., G. Kiddle and R.M. Wallsgrov,1997Carica papaya. ]]>455966Brocklehurst, K. and E. Salih, 1985Carica papaya contains papain multiple forms of chymopapain a and papaya proteinase omega.]]>228525527Cheesbrough, M.,1994Vol. 2,Corazo, J.L.S., L.O. Losada and V.P. Sanjuan,1999162630Czygan, F.C.,19935276282Darout, I.A., A.A. Christy, N. Skaug and P.K. Egeberg,2000321114Ernst, R.K., T. Guina and S.I. Miller,1999179326330Grossman, N. and L. Leive,1984Salmonella lipopolysaccharide is affected by its structure but not its O-antigen length.]]>132376385Gupta, A.K., C.W. Lynde, G.J. Lauzon, M.A. Mahlmauer and S.W. Braddock et al.,1998138529532Levin, J., C.R. Alving, R.S. Munford and P.L. Stotz,1993Vol. 2,MacLeod, A. and N.M. Pieris, 1983Carica papaya L.) with particular reference to glucosinolate products. ]]>3110051008Martin, G.D., H. Chart, E. John Threlfall, E. Morgan, J.M. Lodge, N.L. Brown and J. Stephen, 2000Salmonella serotypes typhimurium and enteriditis of human gastro-enteric origin for rabbit ileum: role of LPS, plasmids and host factors. ]]>4910111021Maskell, D. and A. Allen,1997Salmonella and Bordetella.]]>25850856Muruganandan, S., K. Srinivasan, S. Gupta, P.K. Gupta and J. Lal, 200597497501Nitta, T., T. Arai, H. Takamatsu, Y. Inatomi and H. Murata et al.,2002Staphylococcus aureus.]]>48273276Nkuo-Akenji, T., R. Ndip, A. McThomas and E.C. Fru,200147155158Ody, P.,1993pp: 132-171pp: 132-171Pousset, J.L., B. Boum and A. Cave, 1981Carica papaya bark. ]]>414047Sandhya, R.P. and L. Veerannah, 199644118120Saxen, H., M. Hovi and P.H. Makela,1984Salmonella: O-antigen is important after intraperitoneal but not intravenous challenge.]]>246366Saxen, H., I. Reima and P.H. Makela,1987Salmonella O-polysaccharide as a virulence determinant in the mouse.]]>31528Schwab, W. and P. Schreier, 1988Carica papaya fruit. ]]>2718131816Sheu, F. and Y.T. Shyu, 19964327334Suhaila, M., Z. Hassan and N.A. Hamid, 199417219227Tang, C.S., 197918651652Whitfield, C.,19953178185Winterhalter, P., D. Katzenberger and P. Schreier, 1986Carica papaya fruit.]]>2513471350Zakaria, Z.A., M.N. Somchit, H. Zaiton and A.M. Mat Jais et al .,2006 in vitro antibacterial activity of Corchorus olitorius extracts. ]]>2213215Zakaria, Z.A., H. Zaiton, E.F.P. Henie, A.M.M. Jais and D. Kasthuri et al.,2006in vitro antibacterial activity of Corchorus olitorius and Muntingia calabura extracts.]]>1108114Zhu, X.M., J.X. Song, Z.Z. Huang, Y.M. Wu and M.J. Yu, 1993in vitro. ]]>14452454