Journal of Pharmacology and Toxicology1816-496x2152-100xAcademic Journals Inc.10.3923/jpt.2006.101.107Chamomile recutita Capitula Methanolic Extracts against CCl4-Induced Liver Injury in Rats]]>GuptaAjay Kumar ChitmeHavagiray DassSujata K. MisraNeelam 2200612Antioxidant activity of Methanolic Extract (MET) of capitula of Chamomile recutita was investigated in rats by inducing liver injury with CCl4. The MET exhibited significant antioxidant activity by showing increased levels of Glutathione Peroxidase (GPX), Glutathione-S-Transferase (GST), Glutathione Reductase (GRD), Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione (GSH). The decreased level of Lipid Peroxidation (LPO) has also been shown. The MET,at a dose level of 300 mg kg -1 showed significant antioxidant activity against CCl4 induced liver injury in rats. MET of C. recutita had been shown a potent and prominent free radical scavenging activity and CCl4-intoxicated liver recovery towards normalcy in the methanol extract co-administered rats revealed the effectiveness of C. recutita in combating oxidation stress due to hepatic damage. Thus, the MET possess antioxidant activities with combined hepatoprotective action has a synergistic effect to stabilize cellular membrane or antiperoxidase activity.]]>Achuthan, C.R., B.H. Babu and J. Padikkala,2003Rosa damascena.]]>41357361Aniya, Y., C. Miyagi, A. Nakandakari, S. Kamiya, N. Imaizumi and T. Ichiba,2002Limonium wrightii from the Okinawa islands.]]>9239244Bergmeyer, H.V., K. Gawehn and M. Grassik,1994pp: 348pp: 348Beutler, E., D. Duron and B.M. Kelly,1974pp: 501-503pp: 501-503Bhandarkar, M.R. and A. Khan,2004Nymphaea stellata willd., against carbon tetrachloride-induced hepatic damage in albino rats.]]>916164Bradford, M.M.,197672248254Das, M., G.R. Mallavarapu S. Kumar,1998Chamomilla recutita): Economic botany, biology, chemistry, domestication and cultivation.]]>2010741109Dubler, R.E. and B.M. Anderson,19816597070Eaton, J.W.,199111834Floka, L.,1971324949Gupta, V.K., V. Mallika, Y. Gupta and D. K. Srivastava,19927310Habig, W.H., M.J. Pabst and W.B. Jacoby,197424971307139Halliwell, B., R. Aeschbach, J. Loligger and O.I. Aruoma,199533601617Ilavarasan, R., S. Vasudevan, S. Anbazhagan and S. Venkataraman,200387227230Jakoby, W.B.,1988pp: 375-385pp: 375-385Jose, J.K. and R. Kuttan,1995Emblica officianalis.]]>196370Lawrence, B.M.,1987123552Lawrence, B.M.,1996215262Lin, J.M., C.C. Lin, M.F. Chen, T. Ujiie and A. Takata,1995Mallotus repandus on active oxygen species.]]>46175181Mann, C. and E.J. Stabs,19861236280McCay, P.B., E.K. Lai, J.L. Poyer, C.M. DuBose and E.G. Janzen,1984in vivo and in vitro.]]>25921352143Meister, A. and M.E. Anderson,198352711760Mericli, A.H.,1990Matricaria chamomila variety with no chamazuline in the volatile oil.]]>28145147Misra, H.P. and I. Fridovich,197224731703175Mujumdar, A.M., A.S. Upadhye and A.M. Pradhan,1998Azadirachta indica leaf extract on CCl4 induced hepatic damage in albino rats.]]>60363367Necheles, T.F., T.A. Boles and D.M. Allen,196872319319Ohkawa, H., N. Ohishi and K. Yagi,197995351358Ramaswamy, S.K., P. Briscese, R.J. Garguillo and T. Von Geldern,19881988pp: 951-980pp: 951-980Recknagel, R.O.,1983Status quo and future prospects.]]>4129131Reichling, J., R. Beiderback and H. Becker,1979Matricaria chamomila L.]]>36322332Reichling, J., W. Bisson, H. Becker and G. Schilling,1983Matricaria chamomila Radix.]]>38159161Shylesh, B.S. and J. Padikkala,1999Emilia sonchifolia.]]>70275278Slater, T.F., 1984222115Tappel, A.L.,19733218701874Wilkinson, J.H.,1962pp: 84pp: 84