Journal of Plant Sciences1816-4951xxxx-xxxxxAcademic Journals Inc.10.3923/jps.2007.293.301Momordica charantia Seeds Extract on Membrane Bound ATPases and Lysosomal Hydrolases in Rats with Streptozotocin Diabetes]]>SathishsekarD. RajasekaranS. 3200723The aim of the present study was to examine the effect of an aqueous extract from Momordica charantia seed(s) on membrane bound ATPases and lysosomal hydrolases in the liver and kidney of streptozotocin (STZ)-induced diabetic rats. The rats treated with STZ showed a significant alterations in the activities of membrane bound ATPases and lysosomal hydrolases in the liver and kidney. Oral administration of Momordica charantia seed(s) extract at a dose of 150 mg kg-1 body weight rat-1 day-1 to STZ-induced diabetic rats for a period of 30 days significantly restored the alterations in enzymes activity to near normal level. These results were compared with glibenclamide, a reference drug. Thus, the present study confirms that Momordica charantia seed(s) extractpossesses a significant protective effect on membrane bound ATPases and lysosomal hydrolases.]]>Aubier, M. and N. Viires,199811758766Baynes, J.W.,199140405412Belfiore, F., A.M. Rabuazzo, R. Iannello, Campione and D. Vasta,198635149155Beisswenger, P.G. and R.G. Spiro,1970168596598Bironaite, D. and K. Ollinger,19971033550Bonting, S.L.,19701970pp: 254-363pp: 254-363Brasitus, T.A. and P.K. Dudeja,19852601240512409Conchie, J., A.L. Gelman and G.A. Levry,1967103609615Evans, D.J.,1969Escherichia coli: Activation by calcium ion and inhibition by monovalent cations.]]>100914916Finotti, P. and P. Palatini,1986+-K+) ATPase activity in type 1 (insulin-dependent) diabetic subjects and its activation by homologous plasma.]]>29623628Fushimi, H. and S. Tarui,197476225227Geetha, R.,199331288290Giugliano, D., A. Ceriello and G. Paolisso,199619257267Hjerten, S. and H. Pan,19832+-ATPase from erythrocyte membranes.]]>728281288Hokins, L.E., J.L. Dhal, J.D. Deupree, K.F. Dixon, J.F. Hackney and J.E. Perduce,197324825932605Hultberg, B., J. Linsten and S. Sjoblad,1976155599605Jayasooriya, A.P., M. Sakono, C. Yukizaki, M. Kawano, K. Yamamoto and N. Fukuda,2000Momordica charantia powder on serum glucose levels and various lipid parameters in rats fed with cholesterol-free and cholesterol-enriched diets.]]>72331336Jensen, T., S. Stender and T. Deckert,198831142145Jourdheuil, D.R., Y. Mourayre, P. Vague, J. Boyer and I. Juhan-Vague,1987In vivo insulin effect on ATPase activities in erythrocyte membrane from insulin-dependent diabetics.]]>36991995Kelly, L. and S.H. Woodward,198816491496King, J.,19651965pp: 191-197pp: 191-197Levy, J., D. Rempinski and T.H. Kuo,19942+ + Mg2+) adenosine triphosphatase activity in kidney membranes from streptozotocin non-insulin dependent diabetic rats.]]>43604613Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275McCune, L.M. and T. Johns,200282197205Moore, J.C. and J.E. Morris,198219157159Nerurkar, M.A., J.G. Satav and S.S. Katyare,198831119122Oberley, L.W.,19885113124Ohnishi, T., T. Suzuki, Y. Suzuki and K. Ozawa,19822+-ATPase activities in normal, regenerating and malignant cells.]]>6846774Olsen, I., S. Bon-Gharios and D. Abraham,19902021612170Osicka, T.M., Z. Kiriazis, L.M. Pratt, G. Jerums and W.D. Comper,200144230236Parinandi, N.L., E.D.W. Thompson and H.O.H. Schmid,199010476369Rakieten, N., M.L. Rakieten and M.V. Nadkarni,1963299198Devi, C.R., M.H. Prasad, T.P. Reddy and P.P. Reddy,19975159Sapolsky, A.I., R.D. Altman and D.S. Howell,19733214891493Sasaki, T., S. Matsy and A. Sonae,19721346353Sathishsekar, D., K. Sivagnanam and S. Subramanian,2005Momordica charantia seeds on streptozotocin induced diabetic rats.]]>60383387Sathishsekar, D. and S. Subramanian,2005Momordica charantia seeds in the treatment of STZ-induced diabetes in experimental rats.]]>28978983Sathishsekar, D. and S. Subramanian,2005Momordica charantia (bitter gourd) seeds on Streptozotocin induced diabetic rats.]]>14153158Sathishsekar, D. and S. Subramanian,2006Momordica charantia seeds extract on streptozotocin-induced diabetic rats.]]>64152Shahid, S.M. and T. Mahboob,2003+-K+-ATPase.]]>619711975Sweeney, G. and A. Klip,1998+/K K+-ATPase by insulin: Why and how?]]>182121133Thomas, C.E. and D.J. Reed,199028196105Wattiaux, R.,19772nd Edn.,pp: 165pp: 165Witek, B., T. Krol, A. Kolataj, E. Ochwanowska, I. Stanislawska and A. Sewa,200122238242