Journal of Pharmacy and Allied Health Sciences2224-2503Asian Network for Scientific Information10.3923/jpahs.2014.1.14AggarwalA.K. P. Jindal 1201441Sertaconazole is one of the most effective fungicidal and fungistatic agents.
But its practical use is limited due to its extremely low aqueous solubility
and therefore, search for an adequate delivery system is still a challenging
issue. So, the aim of present study was to modify the crystalline behaviour
of sertaconazole by preparing its solid dispersions so as to increase the solubility
of sertaconazole. Some methods have been reported in literature but these methods
require high amount of carrier which can be toxic in such amount. In the present
study, melting method was used to prepare the solid dispersions and these solid
dispersions were characterized by various techniques in solid as well as in
solution state. Solution state studies showed a profound increase in the solubility
and dissolution rate of sertaconazole with nicotinamide in presence of surfactant
and fatty acid and solid state studies showed an absence of chemical interaction
between sertaconazole and nicotinamide. It is concluded that oleic acid and
tween 80 when combined with sertaconazole and nicotinamide in the solid dispersions
results in profound increase in solubility. So, these dispersions can be used
for oral delivery of sertaconazole and can be considered as better choice for
the treatment of dermatological and gynaecological infections.]]>Aggarwal, A.K. and S. Jain,201159629638Agut, J., C. Palacin, A. Sacristan and J.A. Ortiz,199242718720Ahuja, N., O.P. Katare and B. Singh,2007652638Albet, C., J.M. Fernandez, A. Sacristan and J.A. Ortiz,199242695698Anguiano-Igea, S., F.J. Otero-Espinar, J.L. Vila-Jato and J. Blanco-Mendez,1995705766Tang, B., G. Cheng, J.C. Gu and C.H. Xu,200813606612Carrillo-Munoz, A.J., G. Quindos, O. Del Valle, P. Santos and G. Giusiano et al.,2008In vitro antifungal activity of sertaconazole nitrate against recent isolates of onychomycosis causative agents.]]>20521523Chaulang, G., K. Patil, D. Ghodke, S. Khan and P. Yeole,20081386389Chiou, W.L. and S. Riegelman,19716012811302Craig, D.Q.M.,2002231131144Damian, F., N. Blaton, R. Kinget and G. Van den Mooter,2002® 44/14 and PVP K30.]]>2448798Dhirendra, K., S. Lewis, N. Udupa and K. Atin,200922234246Ford, J.L.,1986616988Gould, S. and R.C. Scott,20054314511459Heo, M.Y., Z.Z. Piao, T.W. Kim, Q.R. Cao, A. Kim and B.J. Lee,200528604611Higuchi, T. and K.A. Connors, 19654212217Martinez-Oharriz, M.C., C. Rodriguez-Espinosa, C. Martin, M.M. Goni, M.C. Tros-Ilarduya and M. Sanchez,200228717725Matsumoto, T. and G. Zografi,19991617221728Mura, P., M.T. Faucci, A. Manderioli, G. Bramanti and P. Parrini,199925257264Newa, M., K.H. Bhandari, D.H. Oh, Y.R. Kim and J.H. Sung et al.,20083114971507Okonogi, S. and S. Puttipipatkhachorn,20067E52E52Ortiz, J.A.,199242689690Palacin, C., C. Tarrago and J.A. Ortiz,2000713746Patel, R.P., D.J. Patel, D.B. Bhimani and J.K. Patel,2008151725Perdomo-Lopez, I., A.I. Rodriguez-Perez, J.M. Yzquierdo-Peiro, A. White, E.G. Estrada, T.G. Villa and J.J. Torres-Labandeira,20029124082415Rasool, A.A., A.A. Hussain and L.W. Dittert,199180387393Rodriguez-Perez, A.I., C. Rodriguez-Tenreiro, C. Alvarez-Lorenzo, P. Taboada, A. Concheiro and J.J. Torres-Labandeira,20069517511762Serajuddin, A.T.M.,19998810581066Suhagia, B.N., H.M. Patel, S.A. Shah, I. Rathod and V.K. Parmar,200656285298Tanaka, N., K. Imai, K. Okimoto, S. Ueda and Y. Tokunaga et al.,2006In vivo evaluation.]]>1125156Marin, M.T., M.V. Margarit and G.E. Salcedo,200257723727Vippagunta, S.R., K.A. Maul, S. Tallavajhala and D.J.W. Grant,2002236111123