Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2018.56.62Curcuma longa Extract]]>SimanjuntakTigor Peniel HattaMochammad RaufSyahrul PrabandariSilvia Arin SiagianCarmen DwiyantiRessy 22018182Background and Objective:Curcuma longa (C. longa) extract has been reported as a potent anti-inflammatory agent. The main objective of this study was to evaluate the effectiveness of Curcuma longa extract to decrease Tumor Necrosis Factor-alpha (TNF-α) and cells damage prevention in early pregnant mice with acute toxoplasmosis. Materials and Methods: This study evaluated 20 early pregnant mice. The mice were divided into five groups (G1-G5). G1-G4 were injected with 10 tachyzoites of Toxoplasma gondii and G5 was not injected. Three days later, G1 and G2 were intervened with C. longa extract dose of 125 mg and 500 mg kg1/day, respectively. G3 was a positive control and G4 was a negative control. G5 was not intervened. The TNF-α level was examined serially (before and 3 days post tachyzoites injection and 3 and 7 days post-intervention). The placental mice were taken 7 days after intervention for histopathology examination. Results: The TNF-α level increased significantly 3 days after tachyzoites injection (p<0.05) and TNF-α level decreased significantly 3 and 7 days after curcuma longa intervention compared to the negative control (p<0.05). Hemorrhagic and necrotic cells were not found in the group intervened with C. longa extract but it found in the positive and negative control groups were 75 and 100%, respectively. Conclusion:Curcuma longa is effective to suppress TNF-α level and prevent placental cells damage in early pregnant mice with acute toxoplasmosis.]]>Tonter, A.M., A.R. Heckeroth and L.M. Weiss,2000Toxoplasma gondii: From animal to human.]]>3012171258Furtado, J.M., J.R. Smith, R. Belfort, Jr., D. Gattey and K.L. Winthrop,20113281284Cunningham, F.G., K.J. Leveno and S.L. Bloom,20142014pp: 1254-1256pp: 1254-1256Alvarado-Esquivel, C., S.J. Pacheco-Vega, J. Hernandez-Tinoco, M.M. Centeno-Tinoco and I. Beristain-Garcia et al.,2014Toxoplasma gondii infection: A cross-sectional study in women in Durango city, Mexico.]]>4117122Villard, O., B. Cimon, C. L’Ollivier, H. Fricker-Hidalgo and N. Godineau et al.,2016Toxoplasma gondii infection: Recommendations from the French National Reference Center for toxoplasmosis.]]>842233Simanjuntak, T.P., M. Hatta, R.H. Sirait, M.B. Karo and L.I. Sirait et al.,2017Toxoplasma gondii on anti-toxoplasma IgG-IgM antibody levels and the outcomes of pregnancy in mice Balb/c.]]>7281289Belloni, A., I. Villena, J.E. Gomez, H. Pelloux and A. Bonhomme et al.,2003Toxoplasma gondii infection in human monocytic cells.]]>89207213Chaouat, G., N. Ledee-Bataille, S. Dubanchet, S. Zourbas, O. Sandra and J. Martal,200413493119Clark, D.A., J.W. Ding, G. Chaouat, C.B. Coulam, C. August and G.A. Levy,1999423743Serranti, D., D. Buonsenso and P. Valentini,201115193198Valentini, P., D. Buonsenso, G. Barone, D. Serranti and R. Calzedda et al.,2015359094Haider, S. and M. Knofler,200930111123Aggarwal, B.B. and K.B. Harikumar,2009414059Guimaraes, M.R., L.S. Coimbra, S.G. de Aquino, L.C. Spolidorio, K.L. Kirkwood and C. Rossa,2011in vivo.]]>46269279Aggarwal, B.B., S.C. Gupta and B. Sung,201316916721692Moghadamtousi, S.Z., H. Abdul Kadir, P. Hassandarvish, H. Tajik, S. Abubakar and K. Zandi,20142014Tyagi, P., M. Singh, H. Kumari, A. Kumari and K. Mukhopadhyay,20152015Grujic, J., O. Djurkovic-Djakovic, A. Nikolic, I. Klun and B. Bobic,200525226230Liu, Q., Z.D. Wang, S.Y. Huang and X.Q. Zhu,2015Toxoplasma gondii.]]>2015Begeman, I.J., J. Lykins, Y. Zhou, B.S. Lai and P. Levigne et al.,2017Toxoplasma gondii IgG/IgM using Toxoplasma ICT IgG-IgM test with sera from the United States and implications for developing countries.]]>2017Guo, Y.Z., P. He and A.M. Feng,201710175178Prigione, I., S. Chiesa, P. Taverna, R. Ceccarelli and R. Frulio et al.,2006Toxoplasma gondii in pregnant women with primary toxoplasmosis.]]>8552560Krishnan, L., L.J. Guilbert, T.G. Wegmann, M. Belosevic and T.R. Mosmann,1996156653662Zenclussen, A.C., K. Gerlof, M.L. Zenclussen, A. Sollwedel and A.Z. Bertoja et al.,2005+CD25+ T regulatory cells prevents fetal rejection in a murine abortion model.]]>166811822Singh, S. and B.B. Aggarwal,19952702499525000Tu, C.T., B. Han, Q.Y. Yao, Y.A. Zhang, H.C. Liu and S.C. Zhang,201212151157