Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2014.303.306MaksoudHussein Metwalli Abdel MolaKhaled El- AwadallahHany 6-82014146-8The aim of this study was to estimate the prevalence of Ig anti-HAV in students aged from 6-12 years old in Damietta Governorate and to identify factors associated with the prevalence of this infection. The present study included 1000 children, aged 6-12 years; selected from pediatric outpatient clinic; regardless of their vaccination history. They were selected during the period from September 2012 to September 2014. The following data related to identification and socio-demographic characteristics were documented: The individual gender, age, residence, number of household members, number of rooms, number of people sleeping together in the same room, family income, educational level of parents or guardians, availability of piped water supply, presence of sewage and the existence and number of bathrooms in the house. Then IgG and IgM were estimated. Age ranged from 6 to 12 years with a mean of 8.87±1.95 years; 56.7% of cases were males, 66.4% live in rural areas, 46.5% of cases were of low socioeconomic standard and 24.2% of middle standard; previous vaccination was reported in 2.7% of cases, active infection reported in 1.9% cases and previous infection (clinical or subclinical) was reported in 86.5% of cases. Finally, ALT cases ranged from 8-65 IU mL-1 with a mean of 12.53±5.40 IU mL-1 and AST ranged from 8-29 with a mean of 12.07±2.56 IU mL-1. Positive cases were younger (7.94±2.09 vs. 8.89±1.94, respectively); of low socioeconomic standards (37.7%), had significantly higher ALT and AST. No case of actively infected group had previous vaccination or old infection. In old infection or vaccination, there was no significant difference between positive and negative cases as regard to age, gender or socioeconomic status. However, there was significant increase of previous vaccination in positive cases (3.1%) when compared to negative cases (0.0%) and significant increase of positive IgM in negative IgG cases. In addition, there was significant increase of liver enzymes in cases negative for IgG when compared to positive cases. There was high endemicity of hepatitis A virus infection in school age children. The active infection reported in minor percentage and the condition was self-limiting. Thus, most positive cases were not vaccinated or had active clinical infection. Seroconversion is due to subclinical infection. Thus, IgG and IgM estimation must be done before vaccination.]]>Bhowmick, K., A. Mammen, P.D. Moses, I. Agarwal, L. Mathew and G. Kang,2005243434Chaves, S.S., N. Darling and T. Santibanez,200958689694Cuthbert, J.A.,2001143858Daniels, D., S. Grytdal and A. Wasley,200958127David, A.M.,20048201209De Alencar Ximenes, R.A., C.M.T. Martelli, E. Merchan-Hamann, U.R. Montarroyos and M.C. Braga et al.,200837852861Gupta, A. and Y. Chawla,200812879Hussain, Z., B.C. Das, S.A. Husain, N.S. Murthy and P. Kar,200621689693Kim, J.H.,200851110118KCDCP.,20122012Kumar, V., A.K. Abbas, N. Fausto and J.C. Aster,20098th Edn.,Previsani, N., D. Lavanchy and A. Hepatitis,20002000Sac, R.U., I. Bostanci, Y. Dallar, G. Cihan and O. Atli,20095158Silva, P.C., C.L. Vitral, C. Barcellos, H. Kawa, R. Gracie and M.L. Rosa,20072315531564Velasco-Mondragon, E., I. Lindong and F. Kamangar,2012140417425Wasley, A., A. Fiore and B.P. Bell,200628101111Yassin, K., R. Awad, A. Tebi, A. Queder and U. Laaser,2001127335339