Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2013.819.823AdnyanaI.K. SukandarE.Y. SetiawanF. ChristantiY. 82013138Quinine is an alkaloid which isolated from the bark of Cinchona sp.,
native plant from South America, especially in Andes Mountains. Beside the function
as an anti-malaria, quinine is used as anti-pyretic, analgesic, treatment for
myotonia and nocturnal leg cramps. Nocturnal leg cramps is common clinical problem
seen most frequently in the elderly. Quinine therapy was reported to be effective
in relieving nocturnal leg cramps. However, due to side effects that appear
limited this used. O-desmethyl quinine (C19H22N2O2)
is one of quinine active metabolites that lost its methyl group. Therefore,
this study was aimed to determine the efficacy and safety O-desmethyl quinine
compared to quinine in treatment nocturnal leg cramps. Mice model were established
by triction and rota rod method. Rats model were established through spinal
cord injury and be evaluated by swimming test for 6 weeks. Test animals of spinal
cord injury method were divided into three group consisted of control group,
group treated with quinine orally at a dose of 26 mg kg-1 b.wt. and
group treated with O-desmethyl quinine orally at a dose 26 mg kg-1
b.wt. On the last day, blood was taken to evaluate hematological profile. O-desmethyl
quinine showed reduction frequency of cramps in rats with spinal cord injury.
Improvement of quinine group was seen at week 6 and on O-desmethyl quinine group
began from week 3 O-desmethyl quinine group showed lower blood toxicity compared
to quinine group.]]>Asnawi, A., A. Nawawi, R.E. Kartasasmita and S. Ibrahim,2011434350Achan, J., A.O. Talisuna, A. Erhart, A. Yeka and J.K. Tibenderana et al.,20112011Bannon, P., P. Yu, J.M. Cook, L. Roy and J.P. Villeneuve,1998715387393Bateman, D.N. and E.H. Dyson,19865215233Dawson, A.A.,1979111951197Fung, M. and J.H.G. Hokbrook,19891514244Gootnick, A.,194371555562Gonzenbach, R.R., P. Gasser, B. Zorner, E. Hochreutener, V. Dietz and M.E. Schwab,2010684857Kumar, R.S., R.S. Sundram, P. Sivakumar, R. Nethaji, V. Senthil, N.V. Murthy and R. Kanagasabi,2008Careya arborea in experimental animal model.]]>33643Jones, K. and C.M. Castleden,198312155158Katzberg, H.D., A.H. Khan and T. Yuen,201074 691696Miller, T.M. and R.B. Layzer,200532431442Mintzer, D.M., S.N. Billet and L. Chmielewski,20092009Nair, K.P.P.,2010pp: 111-129pp: 111-129Padua, L.S. and N. Bunyapraphatsara,1999Pages: 711Pages: 711Sutherland, R., P.C. Vincent, E. Raik, K. Burgess,1977in vitro.]]>1605607