Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2013.814.818Withania somnifera Leaf Extract Loaded Transdermal Gel]]>JoonMonika GargMunish 82013138Several technological advances have been made in the recent years to overcome
skin barrier properties and to enhance drug penetration. In this regard, transdermal
drug delivery system provides a suitable solution of the problems associated
with conventional routes of drug administration. In the present study, Withania
somnifera leaf extract loaded proniosomal gel was prepared and evaluated
for better delivery and improved anti-inflammatory property. The formulated
gel was characterized for vesicle physical analysis, entrapment efficiency and
in vitro release study. The method used for preparation of proniosomal
gel resulted in higher drug entrapment value of 87.2%. Scanning electron microscopy
analysis showed that the surface of the particles was smooth. The formulations
showed prolonged in vitro drug release of 60.8% over a period of 24 h
and significant anti-inflammatory response. From this study, it is concluded
that proniosomes are very stable and promising delivery system for Withania
somnifera leaf extract.]]>Barry, B.W.,200114101114Hu, C. and D.G. Rhodes,19991852335Fang, J.Y., S.Y. Yu, P.C. Wu, Y.B. Huang and Y.H. Tsai,2001In vitro skin permeation of estradiol from various proniosome formulations.]]>2159199Frfkjaer, S., E. Hjorth and O. Wfrtis,19841984pp: 235-245.pp: 235-245.Goyal, C., M. Ahuja and S.K. Sharma,201168147150Gupta, A.P., R.K. Verma, H.O. Mishra and M.M. Gupta,1996Withania somnifera by TLC densitometry.]]>18788790Gupta, G.D. and R.S. Gaud,200668356359Hatziantoniou, S., M. Rallis, C. Demetzos and G. Papaioannou,2000425559Kirjavainen, M., A. Urtti, I. Jaaskelainen, T.M. Suhonen and P. Paronen et al.,1996In vitro-the influence of lipid composition and structure.]]>1304179189Mishra, L.C., B.B. Singh and S. Dagenais,2000Withania somnifera (ashwagandha): A review.]]>5334346Mulgund, S.V., M.S. Phoujdar, S.V. Londhe, P.S. Mallade, T.S. Kulkarni, A.S. Deshpande and K.S. Jain,2009713540Pawar, P., S. Glida, S. Sharma, S. Jagtap and A. Paradkar et al.,2011Withania somnifera root extract expounds anti-inflammatory and mucorestorative activity in TNBS-induced inflammatory bowel disease.]]>2011Scheuplein, R.J., I.H. Blank, G.J. Brauner and D.J.J. MacFarlane,1969526370Sudhamani, T., N. Priyadarisini and M. Radhakrishnan,2010214461454Singh, A., V.A. Saharan, R. Garg and V.B. Gupta,201156974Vora, B., A.J. Khopade and N.K. Jain,199854149165