Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2013.62.66AlabiM.A. SundayR.M. OlowokereT. KareemF.A. OsanaiyeF. 12013131This study was designed to investigate the potential effect of bitters on body
weight, lipid profile (total cholesterol, triglyceride, high density lipoprotein
(HDL)-cholesterol and low density lipoprotein (LDL)-cholesterol), catalase and
lipid peroxidation in the plasma and heart tissue of Albino rats. Three brands
of bitters (Yoyo, Swedish and Living bitters) were administered daily for thirty-two
days through oral rout to age matched twenty eight Albino rats of both sexes.
The rats were grouped into four with seven rats per group. The control group
was administered normal saline, the treatment groups were administered with
Yoyo, Swedish and Living bitters respectively (15 mL kg-1). The animals
were sacrificed after thirty-two days. There was a significant (p<0.05) decrease
in body weight, a reduction in cardiac total cholesterol, lipid peroxidation,
triglyceride and LDL-cholesterol levels and an increase in catalase activity.
There was also a significant reduction in plasma total cholesterol and triglyceride
levels but significant increase in plasma catalase activity. Hence, bitters
could be recommended to be taken as digestive, as it may help to reduced the
body weight, cardiac total cholesterol, triglyceride, LDL-cholesterol levels,
lipid peroxidation level and increase catalase activity.]]>Buege, J.A. and S.D. Aust,19781978pp: 302-310pp: 302-310Bussmann, R.W., A. Glenn, K. Meyer, A. Kuhlman and A. Townesmith,20102010Choi, U.K., O.H. Lee, J.H. Yim, C.W. Cho, Y.K. Rhee, S.I. Lim and Y.C. Kim,2010Taraxacum officinale) Root and Leaf on Cholesterol-Fed Rabbits.]]>116778De Hoff, J.L., L.M. Davidson and D. Kritchevsky,197824433435El-Kamali, H.H. and M.Y. El-Amir,20102143146Jaeschke, H., C.D. Williams, M.R. McGill and A. Farhood,20101624482450Johansson, L.H. and L.A. Borg,1988174331336Kharoubi, D., M. Slimani, D. Krouf, L. Seddik and A. Aoeus,2008Artemisia absinthium) extract on oxidative stress in ameliorating lead induced hematotoxicity.]]>5263270Kim, M. and Y. Kim,20104191195Krishnamoorthy, J.R., M.S. Ranjith and S. Gokulshankar,20092009Mochin, M.C. and J.A. Leyva,1984142281285Motamedi, H., E. Darabpour, M. Gholipour and S.M. Seyyed Nejad,2010In vitro assay for the anti-brucella activity of medicinal plants against tetracycline-resistant Brucella melitensis.]]>11506511Nauck, M., M.S. Graziani, D. Bruton, C. Cobbaert and T.G. Cole et al.,200046506514Ogbonnia, S.O., G.O. Mbaka, N.H. Igbokwe, E.N. Anyika, P. Alli and N. Nwakakwa,2010Leone bitters, a Nigerian polyherbal formulation, in rodents. ]]>1366376Reynolds, T. and A.C. Dweck,1999Aloe vera leaf gel: A review update.]]>68337Sarker, S.D. and L. Nahar,20041114791500Schulz, H. and G. Albroscheit,1988442353361Tariq, M., A.M. Ageel, A.M. Al-Yahya, J.S. Mossa, M.S. Al-Said and N.S. Parmar,1985Commiphora molmol.]]>17381382Verma, H., P.R. Patil, R.M. Kolhapure and V. Gopalkrishna,2008Swertia chirata against herpes simplex viruses: A study by in-vitro and molecular approach.]]>26322326Witztum, J.L. and D. Steinberg,20011193102