Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2013.446.452OyesolaO.A. OyesolaT.O. IzagboA.I. 62013136Fruits have been part of the human diet and supplements. Present study was conducted to investigate pineapple juice (PJ) effects on Gastric Ulcer (GU), since dietary substances or supplements may predispose someone to GU. Thirty-six male wistar rats, weighing 180-200 g were used. They were divided into six groups A-F. Groups A served as control. Group B was not given PJ. Groups C-F received 0.5, 1.0, 1.5 and 2 mL of PJ, respectively. After 30 days, GU was induced with indomethacin. Ulcers Indices (UI) were scored, Total Protein Content (TPC), Catalase (CAT), Superoxide Dismutase (SOD) activities and Lipid Peroxidation (LPP) were determined from stomachs tissue. Significances were taken at p<0.05. UI showed significant increases when groups B-F were compared with control. A significant reduction was seen in TPC when groups B-F were compared with control. Comparison of CAT activities between control and groups B-F showed significant reduction in groups B-F and a significant increase in SOD in groups B-F. Activities of anti-oxidant enzymes in group B were compared with groups C-F. Observation showed that CAT activity increased significantly in groups C and D and SOD activity reduced significantly in groups D-F. Observation from LPP in the gastric mucosa showed increase which was significant in group B, when control was compared with groups B-F. When group B was compared with groups C-F, significant increases were observed in groups C and D. Conclusion from results suggested that PJ consumption may predispose, consumer to gastric ulceration because of its tendency to reduce TPC, increase UI and anti-oxidant enzymes.]]> Adhikary, S.K., W.P. Harkare, K.P. Govindan, K.C. Chikkappaji and S. Saroja et al.,1987252427Nair, A.S., T.K. Abraham and D.S. Jaya,2008Vigna unguiculata L.) varieties.]]>29689691Amidon, G.L., G.A. DeBrincat and N. Najib,199131968973Amure, B.O.,19901990pp: 810Anandan, R., R.D. Rekha, N. Saravanan and T. Devaki,1999Picrorrhiza kurroa against HCl/ethanol-induced ulceration in rats.]]>70498501Bartolome, A.P., P. Ruperez and C. Fuster,1995537579Basil, M.D. and M.S. Howard,19951995pp: 113-161pp: 113-161Bilski, J., J. Saroesiek, V.L.N. Murty, M. Aono and M. Moriga et al.,19873640594065Tochi, B.N., Z. Wang, S.Y. Xu and W. Zhang,20087513520Buege, J.A. and S.D. Aust,19781978pp: 302-310pp: 302-310Duke, J.A.,1983Gmelina arborea Roxb. Handbook of Energy Crops.]]>Food Commission,20092009Fraser, R.J., M. Horowitz, A.F. Maddox, P.E. Harding and B.E. Chatterton et al.,199033675680Góth, L.,1991196143151Priya, G., N. Parminder and S. Jaspreet,201237681Horowitz, M., K. Jones, M.A. Edelbroek, A.J. Smout and N.W. Read,1993105382390Hyams, J.S.,1983843033Ibironke, G.F., S.B. Olaleye, O. Balogun and D.A. Aremu,199711312313Ibu, J.O., I.C. Ezeamuzie and R N. Nwakunala,1986215053Kelly, K.A.,1980239G71G76Kelly, G.S.,19961243257Koletzko, B., P.J. Aggett, J.G. Bindels, P. Bung and P. Ferre et al.,199880S545Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275Marzio, L., P. Formica, F. Fabiani, D. LaPenna and L. Vecchiett et al.,19918614331436Misra, H.P. and I. Fridovich,197224731703175Moore, J.G., P.E. Christian, J.A. Brown, C. Brophy and F. Datz et al.,198429513520Morita, A.H., D.A. Uchida, S.J. Taussig, S.C. Chou and Y. Hokama et al.,1979239340350Nash, Judith, Lambert, Lynn and M. Deakin,19942-receptor.Antagonist in Peptic Ulcer Disease. Evidence for a prophylactic use.]]>47862871Nieper, H.A.,197712614618Okike, J.,19971997Okwu, D.E. and I.N. Emenike,2006216Olaleye, S.B. and E.O. Farombi,2006Garcinia kola seed.]]>201420Olaleye, S.B., Y. Raji, S.A. Onasanwo, P. Erigbali and S.O. Oyesola et al.,20066480484Newby, P.K., D. Muller, J. Hallfrisch, N. Qiao, R. Andres and K.L. Tucker,20037714171425Rapisarda, P., A. Tomaino, R. Lo Cascio, F. Bonina, A. De Pasquale and A. Saija,19994747184723Rifat-uz-Zaman, M.S. Akhtar and M.S. Khan,200479951000Roberfroid, M.B.,2000711682S1687SSamson, J.A.,19862nd Edn.,Tanaka, T., Y. Morioka and U. Gebert,199343558562Taussig, S.J. and H.A. Nieper,19796139151Thomas, J.E.,195737453474Bandyopadhyay, U., D. Das, D. Bandopadhyay, M. Bhattacharjee and K. RanjitBanerjee,1999765563Wenkam, A.,19901st Edn.,pp: 388-506.pp: 388-506.