Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2013.360.366Salmonella
Infections in a Tertiary Care Hospital, Dhaka]]>AfrozHafsa HossainMd. Manjur FakruddinMd. HossainMd. Afzal KhanZahed Uddin Mahmood DattaSuvamoy 52013135Blood stream Salmonella infections range from self-limiting infections
to life-threatening sepsis causing significant mortality and morbidity worldwide
and require rapid and aggressive anti-microbial treatment. The antibiotic resistance
pattern of Salmonella is ever changing over time. Rational and correct
use of antibiotics requires understanding of the pathogen and drug resistance
patterns in a community. This study was conducted to determine the status of
bloodstream Salmonella infection and their antibiotic susceptibility
patterns in a tertiary care hospital at Dhaka, Bangladesh. Six hundred and fifty
six blood samples collected from clinically diagnosed enteric fever patients
from Dhaka Medical college Hospital, Dhaka during January 2012 to December 2012
were processed. Salmonella enterica serovar typhi and paratyphi
isolates were identified by standard microbiological and biochemical procedures.
Ninty four isolates of Salmonella typhi and 59 isolates of S. paratyphi
were isolated. Average prevalence rate of Salmonella in blood was 24.8%.
Young, neonates and elderly persons are more prone to Salmonella infection
and males are more susceptible to Salmonella septicemia than females.
Most of the isolates Salmonella spp. were Multi-drug Resistance (MDR)
and showed high resistance against cefixime, ceftriaxone, cefipime, ciprofloxacin,
chloramphenicol and meropenem. Nalidixic acid was found to be effective against
them. Specific antibiotic utilization strategies like antibiotic restriction,
combination therapy and usage according to the standard antimicrobial susceptibility
testing may help to decrease or prevent the emergence of resistance and incidence
of blood stream infections.]]>Alam, A.S., S. Zaman, F. Chaiti, N. Sheikh and G.K. Kundu,2010348085Afroj, S., M. Ilias, M. Islam and S.K. Saha,2011Salmonella enteric serovar Typhi in Bangladesh.]]>28711Akter, L., M. Hassan and Z. Ahmed,2012Salmonella Typhi and S. Paratyphi in different age group hospitalized patients in dhaka city, Bangladesh.]]>42730Albert, M.J., K. Haider, S. Nahar, A.K.M.G. Kibriya and M.A. Hossain,1991Salmonella typhi in Bangladesh.]]>27554555Bauer, A.W., W.M.M. Kirby, J.C. Sherris and M. Turck,196645493496Bhattacharya, S.S. and U. Das,2000Salmonella typhi infection in Rourkela, Orissa.]]>1117576Chowdhury, A.M.M.A. and M.N. Anwar,2010Salmonella from the Wastes of hospital patients.]]>2769Clinical and Laboratory Standards Institute,20062006Coovadia, Y.M., V. Gathiram, A. Bhamjee, R.M. Garratt and K. Mlisana et al.,1992Salmonella typhi in South Africa.]]>8291100Datta, N., W. Richards and C. Datta,1981Salmonella typhi in vivo acquires resistance to both chloramphenicol and cotrimoxazole.]]>111811183Gautam, V., N.K. Gupta, U. Chaudhary and D.R. Arora,2002Salmonella serotypes in northern India.]]>619Hoque, S.S., A.N. Alam, M.R. Islam and M.R. Khan,1992Salmonella typhi in Bangladesh.]]>161519Islam, M.N., M.E. Rahman, M.A. Rouf, M.N. Islam and M.A. Khaleque et al.,200716149153Jesudason, M.V., B. Malathy and T.J. John,1996Salmonella typhi.]]>103247249Khan, M.R. and S.S. Hoque,1992Salmonella typhi: A need for therapeutic reappraisal.]]>1613Mahmud, A.S.M., M.N. Mahmud and M.A. Hakim,2010Salmonella typhi and some molecular characteristics of fluoroquinolone resistance in indigenous isolates.]]>273841Mills-Robertson, F., M.E. Addy, P. Mensah and S.S. Crupper,2002Salmonella typhi isolated in Ghana.]]>215249253Morshed, M.G., W.A. Khan, H.Z. Khan and M.S. Akbar,1986S.typhi in Bangladesh.]]>42424Rahman, M., A. Ahmad and S. Shoma,2002Salmonella Typhi is not associated with increased incidence of antibiotic susceptible strain in Bangladesh.]]>1292934Rahman, M., A.K. Siddique, S. Shoma, H. Rashid and M.A. Salam et al.,2005134433438Saha, S.K. and S. Saha,1994Salmonella typhi in Bangladesh.]]>33190191Saha, S.K., S.Y. Talukder, M. Islam and S. Saha,1999Salmonella typhi in Bangladesh.]]>18387387Sarker, A.B.M.S., S.K. Saha, M. Islam and M.A. Hossain,2010Salmonella Typhi in Bangladesh.]]>19137144Shadia, K., S.B. Borhan, H. Hasin, S. Rahman and S. Sultana et al.,2011Salmonella Enterica serovar typhi and paratyphi in an urban hospital of dhaka city over 6 years period.]]>54245Shahriar, M. and S. Kabir,2010Salmonella typhi strains from clinical isolates in Dhaka.]]>19207209