Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2013.327.336Solanum nigrum]]>HariRajeswary VasukiR. AnbuJ. MuralikrishnaB. ManasaG. Geethanjali 52013135In the present investigation a comparative analysis of the Free radical scavenging
potential and analgesic activity of the Ethanolic Leaf (ELS) and stem extracts
(ESS) of Solanum nigrum was performed. The extracts were evaluated for
its DPPH and hydroxyl free radicals scavenging effect and inhibitory potential
on protein carbonyl formation. Total phenolic and flavonoid content of the extracts
were also determined by a colorimetric method. The ethanolic extracts of Solanum
nigrum were evaluated for its peripheral analgesic activity by Acetic-acid
induced writhing response and central analgesic activity by Tail flicking method
and Hot plate method in mice. Both the plant extracts scavenged the free radicals
in a dose dependent manner. However the scavenging effect was more pronounced
in ELS extract when comparable to ESS extract. Both the extract possessed considerable
quantity of phenols and flavonoids. In Tail flicking and Hot plate methods the
ELS extract of Solanum nigrum showed higher mean basal latency time when
comparable to ESS extract suggesting its central analgesic activity. Similarly
in Acetic acid induced writhing response the ELS extract exhibited a significant
inhibition of writhing 53.28% when comparable to ESS which exhibited an inhibition
of 46.53%. The positive control Diclofenac sodium showed 70.66% of writhing
inhibition. The analgesic activity of the plants extracts is probably due to
its free radical scavenging activity.]]>An, L., J.J. Tang, X.M. Lin and N.N. Gao,2008Solanum nigrum China.]]>3112251226 Aruoma, O.I.,199875199212Bondet, V., W. Brand-Williams and C. Berset,199730609615Besra, S.E., R.M. Sharma and A. Gomes,1996Litchi chinensis Gaertn (Sapinadaceae).]]>5416D'Amour, F.E. and D.L. Smith,1941727479De Campos, R.O.P., A.R.S. Santos, Z.R. Vaz, T.R. Pinheiro and M.G Pizzolatti et al.,1997Polygala cyparissias (Polygalaceae).]]>6116191630Edeoga, H.O., D.E. Okwu and B.O. Mbaebie,20054685688Eddy, N.B. and D. Leimbach,1953107385393Elisabetsky, E., T.A. Amador, R.R. Albuquerque, D.S. Nunes and A.D.C.T. Carvalho,1995Psychotria colorata (Willd. ex R. and S.) Muell. Arg. alkaloids.]]>487783Freig, D.I., T.M. Reid and L.A. Loeb,19945418901894Gupta, M., U.K. Mazumder, P. Gomathi and V.T. Selvan,2006Plumeria acuminate.]]>2006Ghosh, M.N.,1984pp: 154pp: 154Halliwell, B. and J.M.C. Gutteridge,19993rd Edn.,Pages: 936Pages: 936Halliwell, B., J.M.C. Gutteridge and O.I. Aruoma,1987165215219Huseini, H.F., S.M. Alavian, R. Heshmat, M.R. Heydari and K. Abolmaali,200512619624Hossain, M.M., M.S. Ali, A. Saha and M. Alimuzzaman,2006Paederia foetida.]]>56769Kokate, C.K., A.P. Purohit and S.B. Gokhale,2002Laurence, D.R. and P.N. Bennett,1992pp: 229-256pp: 229-256Lin, H.M., H.C. Tseng, C.J. Wang, J.J. Lin, C.W. Lo and F.P. Chou,2008Soalnum nigrum Linn extract against CCl4 induced oxidative damage in rats.]]>171283293Lee, S.J., J.H. Ko, K. Lim and K.T. Lim,2005Solanum nigrum Linne enhances activities of detoxicant enzymes and lowers plasmic cholesterol in mouse.]]>51399408Planas, E., S. Sanchez, L. Rodriguez, O. Pol and M.M. Puig,200060121127Pal, S., T. Sen and A.K.N. Chaudhuri,1999Bryophyllum pinnatum leaf extract.]]>51313318Rollet-Labelle, E., M.J. Grange, C. Elbim, C. Marquetty, M.A. Gougerot-Pocidalo and C. Pasquier,199824563572Reznick, A.Z. and L. Packer,1994233357363Rice-Evans, C.A., N.J. Miller and G. Paganga,199620933956Ribeiro, R.A., M.L. Vale, S.M. Thomazzi, A.B.P. Paschoalato, S. Poole, S.H. Ferreira and F.Q. Cunha,2000387111118Rajnarayana, K., M.S. Reddy, M.R. Chaluvadi and D.R. Krishna,200133216Ramesh, M., Y.N. Rao, A.V.N.A. Rao, M.C. Prabhakar, C.S. Rao, N. Muralidhar and B.M. Reddy,1998Caralluma attenuata.]]>626366Ramaswamy, S., N.P. Pillai, V. Gopalkrishnan, N.S . Parmar and M.N. Ghosh,198523219220Shimada, K., K. Fujikawa, K. Yahara and T. Nakamura,199240945948Slinkard, K. and V.L. Singleton,1977284955Saha, A., M.A. Masud, S.C. Bachar, J.K. Kundu, B.K. Datta, L. Nahar and S.D. Sarker,2007Phyllanthus reticulatus. in mice model.]]>45335359Stadtman, E.R. and C.N. Oliver,200526620052008Saleem, T.S.M., S. Ramkanth, C.M. Chetty, M. Alagusundaram, K. Gnanaprakash, V.S.T. Rajan and S. Angalaparameswari,2009Solanum nigrum L.: A review.]]>3342345Voilley, N.,200437179Wang, B.S., S.S. Lin, W.C. Hsiao, J.J. Fan, L.F. Fuh and P.D. Duh,200698149157Zhishen, J., T. Mengcheng and W. Jianming,199964555559Kumar, V.P., S. Shasidharara, M.M. Kumar and B.Y. Sridhara,2006Solanum nigrum against gentamicin induced kidney cell (vero cells) damage in vitro.]]>72481486