Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2012.99.106Luffa echinata Seed Extract]]>SharmaT. AroraR. GillN.S. 42012124The different parts of Luffa echinata Bindaal
plant are traditionally claimed and scientifically proved to be used in Liver
disorders, jaundice, poisoning and migraine as antioxidant etc. but seeds part
of this plant has not been explored yet. The present study was designed to investigate
the free radical scavenging, anti-inflammatory and analgesic potential of methanolic
extract of Luffa echinata seeds (MELE). Free radical scavenging potential
of MELE was evaluated by DPPH (1,1-diphenyl-2-picrylhydrazyl method). The extract
showed significant (p<0.05) free radical scavenging activity in dose dependent
manner as compared with Ascorbic acid. The maximum free radical scavenging activity
of MELE was found to be 82.34% at concentration of 150 μg mL-1
by the DPPH free radical scavenging method. Antioxidant effect was also investigated
qualitatively using 1,1-diphenyl-2-picrylhydrazyl. The extract was further evaluated
for its anti-inflammatory activity by using carrageenan-induced paw oedema in
rats. Analgesic activity was evaluated by tail immersion and Hot plate methods
in mice. Anti -inflammatory and analgesic activities were evaluated at dose
level 50, 150 and 200 mg kg-1. The extract showed significant decrease
in paw volume (60.57% reduction) and analgesic effect shown at the dose level
of 200 mg kg-1 as compared to the reference drug diclofenac sodium.
The MELE may be useful as a natural antioxidant in the treatment of inflammation
and pain.]]>Agrahari, A.K., K. Khaliquzzama and S.K. Panda,2010Trapanatans var. bispinos rorb. roots.]]>1811Ahmad, F., R.A. Khan and S. Rasheed,19925111114Ahmed, B., T. Alam and S.A. Khan,2001Luffa echinata fruits.]]>76187189Ajmal, A.M.,20109911641164Chaudhary, G.D., P. Kamboj, I. Singh and A.N. Kalia,20104397408Dhiman, K., A. Gupta, D.K. Sharma, N.S. Gill and A. Goyal,201241626Di Rosa, M., J.P. Giroud and D.A. Willoughby,19711041529Uma, R., V. Sivasubramanian and S.N. Devaraj,2011in vitro antioxidant activities and antiproliferative activity of green microalgae,Desmococcus olivaceous and Chlorococcum humicola.]]>28293Ganie, S.A., M.A. Zargar, A. Masood and E. Haq,2010In vitro and in vivo evaluation of free radical scavenging potential of ethanolic extract of Podophyllum hexandrum.]]>4196203Gill, N.S., K. Dhiman, J. Bajwa, P. Sharma and S. Sood,2010Benincasa hispida seed extract.]]>6652657Rahman, A.S.H.,2003Lagenaria siceraria) a vegetable for good health.]]>2249256Hameed, M.A., F. Amir, K.Y. Chin and S. Fathima,2011Aegle marmelos.]]>29094Hamid, A.A., O.O. Aiyelaagbe, L.A. Usman, O.M. Ameen and A. Lawal,20104142151Khalaf, N.A., A.K. Shakya, A. Al-Othman, Z. El-Agbar and H. Farah,2008325155Kumar, C.H., A. Ramesh, J.S. Kumar and B.M. Ishaq,20112501515Kumar, V.P., S. Sashidhara, M.M. Kumar and B.Y. Shidhara,2000Luffa echinata on lipid peroxidation and free radical scavenging activity.]]>52891894Meena, M.C. and V. Patni,2008Citrullus colocynthis (Linn.) Schrad.]]>22137142Musa, A.M., A.B. Aliyu, A.H. Yaro, M.G. Magaji, H.S. Hassan and M.I. Abdullahi,2009Anisopus mannii (N.E.Br) (Asclepiadaceae) in rodents.]]>3374378Muthumani, P., R. Meera, S. Mary, Jeenamathew, P. Devi, B. Kameswari and B. Eswara priya,2010Luffa cylindrical.]]>11122Samy, R.P. and P. Gopalakrishanakone,2007111761176Ramesh, C.K., K.L. Raghu, K.S. Jamuna, G.S. Joyce, R.S.V. Mala and B.R. Vijay Avin,201128694Farhan, H., H. Rammal, A. Hijazi and B. Badran,2012Malva parviflora L.]]>45559Sannigrahi, S., S. Parida, V.J. Patro, U.S. Mishra and A. Pathak,2010Pterospermum acerifolium.]]>215Saraswathi, R., L. Upadhyay, R. Venkatakrishnan, R. Meera and P. Devi,2011Abutilon indicum Linn.]]>3154156Sharma, U.S., U.K. Sharma, N. Sutar, A. Singh and D.K. Shukla,2010Cordia dichotoma forst f. seeds extracts.]]>214Subhan, N., M.A. Alam, F. Ahmed, M.A. Awal, L. Nahar and S.D. Sarker,2008In vitro antioxidant property of the extract of Excoecaria agallocha (Euphorbiaceae).]]>16149154Vankar, P.S., V. Tiwari, L.W. Singh and N. Swapana,2006513181322Verma, S. and S.P. Singh,20081347350Yadav, R.K., D.S. Yadav and P. Sarma,200513111