Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2012.51.56FakhrjouAshraf ToutounchiSeyed Javad Seyed 22012122Oral lichen planus is not a rare condition in human being. This inflammatory disease is generally regarded as a benign pathology; however, transformation toward malignant conditions in some cases has forced many physicians to consider lichen planus as a premalignant entity. This study investigates and compares the rate of Ki-67 and P53 expression in patients with oral lichen planus and oral Squamous Cell Carcinoma (SCC) in comparison with normal subjects. In this prospective study, paraffin-embedded specimens of histopathologically proved oral lichen planus (n = 30), oral SCC (n = 20) and oral buccal mucosa of normal subjects (n = 20) were examined at Tabriz Imam Reza Hospital within a one-year period of time. Monoclonal antibodies against Ki-67 and P53 were used for determining the rate of expression of these two markers. The three groups were matched for patients age and gender. Ki-67 was expressed in 26 patients (86.7%) in lichen planus group, in 20 patients (100%) in SCC group and in 4 normal subjects (20%). The rate of Ki-67 positivity was significantly higher in lichen planus and SCC groups than in normal subjects (p<0.001). P53 was positive in 26 patients (86.7%) in lichen planus group, in 20 patients (100%) in SCC group and in 8 normal subjects (40%). The rate of P53 positivity was significantly higher in lichen planus and SCC groups than in normal subjects (p<0.001). In conclusion, this study confirmed that lichen planus could be regarded as a potentially premalignant condition.]]>Abdel-Hamid, M., S. Ezzat, S. El-Kafrawy, S. Abdel-Latif and M. El-Daly et al.,200515757Abdelmeguid, N.E., M.H. Mostafa, A.M. Abdel-Moneim, A.F. Badawi and N.S. Abou Zeinab,200848191Acay, R.R., C.R. Felizzola, N. de Araujo and S.O. de Sousa,200642475480Al-Haggar, M.S., A.A. Settin, M. Ragab, M. Al-Shahat and H. Abdel-Hadi et al.,20066906914Al-Qahtani, A.A. and M.S. Aly,20073127133Bidgoli, S.A., E. Azizi and M.D. Zavarhei,20071033503355Bin-Meferij, M.M.,2009Spirulina sp. against cancer in experimental animals.]]>53643De Sousa, F.A.C.G., T.C. Paradella, Y.R. Carvalho and L.E.B. Rosa,200913308312El-Kott, A.F. and A.A. Owayss,20083402408Gohari, M.R., M. Mahmoudi, K. Mohammad, Y. Pasha and R. Khodabakhshi,200621018Gonzalez-Moles, M.A., C. Bascones-Ilundain, J.A. Gil Montoya, I. Ruiz-Avila, M. Delgado-Rodriguez and A. Bascones-Martinez,20065110931103Kabbinejadian, S., S. Fouladdel, M. Ramezani and E. Azizi,20088380385Priya, D.K.D., R. Gayathri, G.R. Gunassekaran, S. Murugan and D. Sakthisekaran,20116395405Mansourian, A., M. Sanatkhani and F.M. Heravi,20088201204Mattila, R., K. Alanen and S. Syrjanen,2007298381388Rezaii, J., H. Ashegh, M. Hasibi, M. Behzadi, F. Khodadadi and M. Heidarali,20088564568Roopashree, M.R., R.V. Gondhalekar, M.C. Shashikanth, J. George, S.H. Thippeswamy and A. Shukla,201039729734Safadi, R.A., S.Z. Al-Jaber, H.M. Hammad and A.A. Hamasha,201055454461Sohrabi, M. F.A. Kalati, S. Vatansever, M.M. Abbasi and L. Roshangar et al .,200912750757Sousa, F.A., T.C. Paradella, Y.R. Carvalho and L.E. Rosa,200951117121Talghini, S., M. Halimi and H. Baybordi,200912929933Taniguchi, Y., T. Nagao, H. Maeda, Y. Kameyama and K.A. Warnakulasuriya,200235103109Van der Meij, E.H., K.P. Schepman and I. van der Waal,200396164171Xue, J.L., M.W. Fan, S.Z. Wang, X.M. Chen, Y. Li and L. Wang,200534467472Zekri, A.R.N., H.M.A. El-Din, M.M. Hafez and A.A. Bahnassy,200516464Agha-Hosseini, F., M. Khalili and B. Rohani,2009V383743Hietanen, J., M.R. Paasonen, M. Kuhlefelt and M. Malmstrom,199935278282Piattelli, A., C. Rubini, M. Fioroni, G. Iezzi and A. Santinelli,200260532540